Phenolics-Rich Extract from Agarwood Leaf-Tea Alleviate Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis Via Modulating Intestinal Barrier Function, Liver Inflammation, and Gut Microbiota

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2024-11-21 DOI:10.1002/mnfr.202400566

Ruyan Fan, Wensong Wei, Youjing Wei, Xue Lin, Shaobo Zhou, Lu Wang

引用次数: 0

Abstract

At present, the incidence rate of ulcerative colitis (UC) continues to increase, causing a global burden. In addition, therapeutic drugs have great side effects. According to modern pharmacology, agarwood leaves have anti-inflammatory, antibacterial, hypoglycemic, and lipid-lowering effects. Therefore, this experiment on DSS induced colitis treatment of polyphenolic substances in agarwood leaves is feasible and in line with the current hot topic of using natural substances instead of drugs for treatment.

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从沉香叶茶中提取的富含酚类的提取物通过调节肠道屏障功能、肝脏炎症和肠道微生物群缓解右旋糖酐硫酸钠（DSS）诱发的溃疡性结肠炎

目前，溃疡性结肠炎（UC）的发病率持续上升，给全球造成了负担。此外，治疗药物的副作用也很大。根据现代药理学，沉香叶具有抗炎、抗菌、降血糖、降血脂等作用。因此，本实验利用沉香叶中的多酚类物质治疗 DSS 引起的结肠炎是可行的，也符合当前利用天然物质代替药物进行治疗的热门话题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.