Single-Cell Membrane Potential Stimulation and Recording by an Electrolyte-Gated Organic Field-Effect Transistor

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Electronic Materials Pub Date : 2024-11-19 DOI:10.1002/aelm.202400134

Nicolò Lago, Alessandra Galli, Sarah Tonello, Sara Ruiz-Molina, Saralea Marino, Stefano Casalini, Marco Buonomo, Simona Pisu, Marta Mas-Torrent, Giada Giorgi, Morten Gram Pedersen, Mario Bortolozzi, Andrea Cester

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Abstract

The reliable stimulation and recording of electrical activity in single cells by means of organic bio-electronics will be an important milestone in developing new low-cost and highly biocompatible medical devices. This paper demonstrates extracellular voltage stimulation and single-cell membrane potential recording by means of a dual-gate electrolyte-gated organic field-effect transistors (EGOFET) employing 2,8-Difluoro-5,11-bis(triethylsilylethynyl)anthradithiophene blended with polystyrene as active material. To obtain a sufficiently small footprint to allow bidirectional communication at the single cell level, the EGOFET technology has been scaled down implementing a Corbino layout, paving the way to the development of novel bidirectional Electrocorticography (ECoG) devices with a high spatial resolution. A specific and thorough analysis of the working mechanisms of EGOFET-based bio-sensors is reported, highlighting the importance of the device design and using an appropriate batch of measurements for the recording of the electrical activity of cells.

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电解质门控有机场效应晶体管的单细胞膜电位刺激和记录功能

利用有机生物电子技术可靠地刺激和记录单细胞的电活动，将是开发新型低成本、高生物相容性医疗设备的一个重要里程碑。本文通过采用 2,8-Difluoro-5,11-bis(triethylsilylethynyl)anthradithiophene 与聚苯乙烯混合作为活性材料的双栅电解质门控有机场效应晶体管（EGOFET），展示了细胞外电压刺激和单细胞膜电位记录。为了获得足够小的基底面，以便在单细胞层面实现双向通信，EGOFET 技术采用了 Corbino 布局，为开发具有高空间分辨率的新型双向脑电图（ECoG）设备铺平了道路。报告对基于 EGOFET 的生物传感器的工作机制进行了具体而透彻的分析，强调了设备设计和使用适当的测量批次记录细胞电活动的重要性。

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来源期刊

Advanced Electronic Materials NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

11.00

自引率

3.20%

发文量

433

期刊介绍： Advanced Electronic Materials is an interdisciplinary forum for peer-reviewed, high-quality, high-impact research in the fields of materials science, physics, and engineering of electronic and magnetic materials. It includes research on physics and physical properties of electronic and magnetic materials, spintronics, electronics, device physics and engineering, micro- and nano-electromechanical systems, and organic electronics, in addition to fundamental research.