Astrocytic proteostasis in the tale of aging and neurodegeneration

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-11-16 DOI:10.1016/j.arr.2024.102580

Felipe Cabral-Miranda , Isadora Matias , Flávia Carvalho Alcantara Gomes

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引用次数: 0

Abstract

Homeostasis of proteins (proteostasis), which governs protein processing, folding, quality control, and degradation, is a fundamental cellular process that plays a pivotal role in various neurodegenerative diseases and in the natural aging process of the mammalian brain. While the role of neuronal proteostasis in neuronal physiology is well characterized, the contribution of proteostasis of glial cells, particularly of astrocytes, has received fairly less attention in this context. Here, we summarize recent data highlighting proteostasis dysfunction in astrocytes and its putative implication to neurodegenerative diseases and aging. We discuss how distinct proteostasis nodes and pathways in astrocytes may specifically contribute to brain function and different age-associated pathologies. Finally, we argue that the understanding of astrocytic proteostasis role in neuronal physiology and functional decay may arise as a potential new avenue of intervention in neurodegenerative diseases and grant relevant data in the biology of aging.

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衰老和神经退行性变中的星形胶质细胞蛋白稳态

蛋白质的稳态（蛋白稳态）控制着蛋白质的加工、折叠、质量控制和降解，是一个基本的细胞过程，在各种神经退行性疾病和哺乳动物大脑的自然衰老过程中起着关键作用。虽然神经元蛋白稳态在神经元生理学中的作用已被充分描述，但神经胶质细胞（尤其是星形胶质细胞）的蛋白稳态在这方面的贡献却较少受到关注。在此，我们总结了最近的一些数据，这些数据强调了星形胶质细胞的蛋白稳态功能障碍及其对神经退行性疾病和衰老的潜在影响。我们讨论了星形胶质细胞中不同的蛋白稳态节点和通路是如何对大脑功能和不同年龄相关病症做出特殊贡献的。最后，我们认为，了解星形胶质细胞蛋白稳态在神经元生理和功能衰退中的作用可能会成为干预神经退行性疾病的潜在新途径，并为衰老生物学提供相关数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.