Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective

IF 6.7 2区医学 Q1 NEUROSCIENCES

Progress in Neurobiology Pub Date : 2024-11-01 DOI:10.1016/j.pneurobio.2024.102685

Konstantin Yenkoyan , Artem Grigoryan , Viera Kutna , Susan Shorter , Valerie B. O’Leary , Reza Asadollahi , Saak V. Ovsepian

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Abstract

Functional and molecular alterations in the cerebellum are among the most widely recognised associates of autism spectrum disorders (ASD). As a critical computational hub of the brain, the cerebellum controls and coordinates a range of motor, affective and cognitive processes. Despite well-described circuits and integrative mechanisms, specific changes that underlie cerebellar impairments in ASD remain elusive. Studies in experimental animals have been critical in uncovering molecular pathology and neuro-behavioural correlates, providing a model for investigating complex disease conditions. Herein, we review commonalities and differences of the most extensively characterised genetic lines of ASD with reference to the cerebellum. We revisit structural, functional, and molecular alterations which may contribute to neurobehavioral phenotypes. The cross-model analysis of this study provides an integrated outlook on the role of cerebellar alterations in pathobiology of ASD that may benefit future translational research and development of therapies.

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自闭症谱系障碍遗传模型中的小脑损伤：神经生物学视角

小脑的功能和分子改变是自闭症谱系障碍（ASD）最广为人知的关联之一。作为大脑的重要计算枢纽，小脑控制并协调着一系列运动、情感和认知过程。尽管小脑回路和整合机制得到了很好的描述，但自闭症谱系障碍中小脑功能障碍的具体变化仍然难以捉摸。实验动物研究对于揭示分子病理学和神经行为相关性至关重要，为研究复杂的疾病状况提供了一个模型。在此，我们回顾了小脑方面最广泛表征的 ASD 遗传系的共性和差异。我们重新审视了可能导致神经行为表型的结构、功能和分子改变。本研究的跨模型分析为小脑改变在 ASD 病理生物学中的作用提供了一个综合的前景，这可能有利于未来的转化研究和疗法开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Neurobiology 医学-神经科学

CiteScore

12.80

自引率

1.50%

发文量

107

审稿时长

33 days

期刊介绍： Progress in Neurobiology is an international journal that publishes groundbreaking original research, comprehensive review articles and opinion pieces written by leading researchers. The journal welcomes contributions from the broad field of neuroscience that apply neurophysiological, biochemical, pharmacological, molecular biological, anatomical, computational and behavioral analyses to problems of molecular, cellular, developmental, systems, and clinical neuroscience.