Maternal iron nutrition during pregnancy and fetal intrauterine growth.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-11-09 DOI:10.1186/s12937-024-01042-z

Jiaomei Yang, Qianqian Chang, Qiancheng Du, Xin Liu, Shaonong Dang, Xueye Tian

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引用次数: 0

Abstract

Background: Iron is critical for maternal and fetal health; however, the effect of iron nutrition on fetal intrauterine growth remains unclear. This study aimed to investigate the associations of maternal iron nutrition during pregnancy with fetal intrauterine growth parameters among the Chinese population.

Methods: This retrospective birth cohort study included 482 pregnant women. Maternal information was collected by standard questionnaires. Maternal concentrations of serum ferritin and hemoglobin were detected. Fetal ultrasound examinations in the second and third trimesters were conducted. Quantile regression or linear regression models were applied to assess the associations.

Results: Participants took iron supplementation in early, mid, and late pregnancy accounted for 19.1%, 40.3%, and 37.8%, respectively. Iron supplementation in the first and second trimesters and total iron intake in pregnancy were positively associated with fetal intrauterine growth parameters at some percentiles. Compared with those without iron supplementation in the second trimester, women with iron supplementation in the second trimester had 0.37 (95%CI = 0.24-0.49), 0.37 (95%CI = 0.26-0.48), 0.15 (95%CI = 0.04-0.26), and 0.52 (95%CI = 0.42-0.61) higher z-scores in fetal biparietal diameter, femur length, abdominal circumference, and estimated fetal weight at the 50th percentile in the second trimester, respectively. Maternal serum ferritin and hemoglobin concentrations in the first and second trimesters were positively correlated with several fetal growth parameters.

Conclusions: Fetal intrauterine growth may benefit from maternal iron nutrition in the first and second trimesters.

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孕期母体铁营养与胎儿宫内发育。

背景：铁对母体和胎儿的健康至关重要，但铁营养对胎儿宫内生长的影响仍不清楚。本研究旨在调查中国孕妇孕期铁营养与胎儿宫内生长参数的关系：这项回顾性出生队列研究纳入了 482 名孕妇。方法：这项回顾性出生队列研究共纳入了 482 名孕妇，通过标准问卷收集了孕产妇信息。检测了孕妇血清铁蛋白和血红蛋白的浓度。在第二和第三个孕期进行了胎儿超声波检查。采用量子回归或线性回归模型评估相关性：结果：在孕早期、孕中期和孕晚期服用铁剂的孕妇分别占 19.1%、40.3% 和 37.8%。妊娠头三个月和后三个月的铁质补充量以及孕期铁质总摄入量与胎儿宫内生长参数的某些百分位数呈正相关。与后三个月未补充铁剂的孕妇相比，后三个月补充铁剂的孕妇的胎儿宫内生长参数分别为 0.37（95%CI = 0.24-0.49）、0.37（95%CI = 0.26-0.48）、0.15（95%CI = 0.在第二孕期，胎儿双顶径、股骨长、腹围和估计胎儿体重的 Z 值分别比第 50 百分位数高 0.15（95%CI = 0.04-0.26）、0.52（95%CI = 0.42-0.61）和 0.52（95%CI = 0.42-0.61）。妊娠头三个月和后三个月的母体血清铁蛋白和血红蛋白浓度与胎儿的几个生长参数呈正相关：胎儿宫内生长可能得益于妊娠头三个月和后三个月母体的铁营养。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.