Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-11-09 DOI:10.1186/s12937-024-01044-x

Asieh Mansour, Sayed Mahmoud Sajjadi-Jazi, Maryam Mirahmad, Pooria Asili, Maryam Sharafkhah, Sahar Masoudi, Hossein Poustchi, Akram Pourshams, Maryam Hashemian, Azita Hekmatdoost, Reza Malekzadeh

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引用次数: 0

Abstract

Background: Less is known whether the amino acid composition of dietary protein sources effects on long-term health outcomes. We aimed to evaluate the association between dietary amino acid composition and all-cause and cause-specific mortality.

Methods: This study used data from the Golestan Cohort Study, which was performed in the Golestan Province of Iran from January 2004 to June 2008. Mortality, which was the primary outcome, was ascertained through September 2022. The Cox proportional hazards regression models were used to determine the adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality according to the quintiles of amino acid consumption, taking the third quintile as the reference.

Results: A total of 47,337 participants (27,293 [57.7%] women) with a mean (standard deviation) age of 51.9 (8.9) years were included. During a median follow-up of 15 years, 9,231 deaths were documented. Regarding essential amino acid intakes, the HRs of all-cause mortality were 1.16 (95% CI, 1.07-1.26) in the first quintile, compared with the reference group (P for non-linear trend < 0.001). Similarly, non-linear associations were observed between risk of all-cause mortality and intake of branched-chain, aromatic, sulfur-containing, or non-essential amino acids (P for non-linear trend < 0.001 for all comparisons), with higher HRs for participants in the first quintiles. There was an age interaction for the associations between dietary amino acids and mortality (P for interaction ˂0.05). While high amino acid diets were detrimental in middle-aged adults (< 65 years), increased hazards of mortality were observed among older adults (≥ 65 years) with low amino acid intake.

Conclusions: This study showed the non-linear trend between amino acids intake and risk of mortality in the middle-aged and older Iranian population. Overall, our findings suggest that diets lower in amino acids were associated with increased hazards of mortality, particularly among older adults.

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膳食氨基酸摄入量与全因和特定原因死亡率：戈勒斯坦队列研究的结果。

背景：人们对膳食蛋白质来源的氨基酸组成是否会影响长期健康结果知之甚少。我们旨在评估膳食氨基酸组成与全因死亡率和特定原因死亡率之间的关系：本研究使用了戈勒斯坦队列研究的数据，该研究于 2004 年 1 月至 2008 年 6 月在伊朗戈勒斯坦省进行。主要研究结果是截至 2022 年 9 月的死亡率。研究采用 Cox 比例危险回归模型，以第三五分位数为参考，根据氨基酸摄入量的五分位数确定死亡率的调整后危险比（HR）和 95% 置信区间（CI）：共纳入 47,337 名参与者（27,293 名[57.7%]女性），平均（标准差）年龄为 51.9（8.9）岁。在中位数为 15 年的随访期间，共记录了 9,231 例死亡病例。在必需氨基酸摄入量方面，与参照组相比，第一五分位组的全因死亡率的 HR 值为 1.16（95% CI，1.07-1.26）（P 为非线性趋势结论）：这项研究表明，在伊朗中老年人群中，氨基酸摄入量与死亡风险之间存在非线性趋势。总体而言，我们的研究结果表明，氨基酸含量较低的饮食与死亡率风险增加有关，尤其是在老年人中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.