Optimising detection of thrombosis in paediatric Staphylococcus aureus bacteraemia: A prospective interventional sub-study protocol

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2024-11-13 DOI:10.1016/j.idnow.2024.105010

Keerthi Anpalagan , Asha C. Bowen , Leanne Lamborn , Derek Roebuck , Tina Carter , Jeffrey W. Cannon , Caitlin Symons , Jane McNally , Gillian Woods , Brendan McMullan , Amanda Gwee , Steven Y.C. Tong , Joshua S. Davis , Anita J. Campbell

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Abstract

Introduction

Staphylococcus aureus bacteraemia (SAB) is the most common cause of sepsis, contributing to paediatric intensive care unit admission in Australia and New Zealand. While deep venous thrombosis (DVT) has been reported in children with invasive S. aureus infections, the actual frequency and possible effects of thrombosis on disease severity and outcome in paediatric SAB remain unknown. Moreover, guidance regarding imaging for paediatric SAB management are poorly defined.

Methods and analysis

We report the protocol for the SNOOPY (Staphylococcus aureus Network; ultrasOund for diagnOsis of endovascular disease in Paediatrics and Youth) study. SNOOPY is a pilot prospective single-arm interventional study that aims to investigate the proportion of children with SAB that have venous thrombosis detected using whole body doppler ultrasound.

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优化儿科金黄色葡萄球菌菌血症血栓检测：前瞻性介入子研究方案。

导言：金黄色葡萄球菌菌血症（SAB）是败血症最常见的病因，也是澳大利亚和新西兰儿童入住重症监护病房的主要原因。虽然有报道称在患侵袭性金葡菌感染的儿童中存在深静脉血栓（DVT），但血栓形成的实际发生频率以及对儿科 SAB 疾病严重程度和预后可能产生的影响仍不得而知。此外，有关儿科 SAB 管理的影像学指导也不明确：我们报告了 SNOOPY（金黄色葡萄球菌网络；儿科和青少年血管内疾病超声诊断）研究的方案。SNOOPY 是一项试验性前瞻性单臂介入研究，旨在调查使用全身多普勒超声检测到静脉血栓形成的 SAB 患儿比例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious diseases now Medicine-Infectious Diseases

CiteScore

7.10

自引率

2.90%

发文量

116

审稿时长

40 days