Neuronal basis of high frequency fMRI fluctuation: direct evidence from simultaneous recording.

IF 2.4 3区医学 Q3 NEUROSCIENCES

Frontiers in Human Neuroscience Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI:10.3389/fnhum.2024.1501310

Yang Qiao, Hanbing Lu, Yihong Yang, Yufeng Zang

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Abstract

Resting-state functional magnetic resonance imaging (RS-fMRI) has been extensively utilized for noninvasive investigation of human brain activity. While studies employing simultaneous recordings of fMRI and electrophysiology have established a connection between the low-frequency fluctuation (< 0.1 Hz) observed in RS-fMRI and the local field potential (LFP), it remains unclear whether the RS-fMRI signal exhibits frequency-dependent modulation, which is a well-documented phenomenon in LFP. The present study concurrently recorded resting-state functional magnetic resonance imaging (RS-fMRI) and local field potentials (LFP) in the striatum of 8 rats before and after a pharmacological manipulation. We observed a highly similar frequency-dependent pattern of amplitude changes in both RS-fMRI and LFP following the manipulation, specifically an increase in high-frequency band amplitudes accompanied by a decrease in low-frequency band amplitudes. These findings provide direct evidence that the enhanced high-frequency fluctuations and reduced low-frequency fluctuations observed in RS-fMRI may reflect heightened neuronal activity.

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高频 fMRI 波动的神经元基础：同步记录的直接证据。

静息态功能磁共振成像（RS-fMRI）已被广泛用于人类大脑活动的无创研究。虽然采用同步记录 fMRI 和电生理学的研究已经确定了 RS-fMRI 中观察到的低频波动（< 0.1 Hz）与局部场电位（LFP）之间的联系，但 RS-fMRI 信号是否表现出频率依赖性调制（这是 LFP 中的一种有据可查的现象）仍不清楚。本研究同时记录了 8 只大鼠在药理操作前后纹状体的静息态功能磁共振成像（RS-fMRI）和局部场电位（LFP）。我们观察到操纵后 RS-fMRI 和 LFP 的振幅变化具有高度相似的频率依赖性模式，特别是高频段振幅增加，低频段振幅减少。这些发现提供了直接证据，证明在 RS-fMRI 中观察到的高频波动增强和低频波动减弱可能反映了神经元活动的增强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Human Neuroscience 医学-神经科学

CiteScore

4.70

自引率

6.90%

发文量

830

审稿时长

2-4 weeks

期刊介绍： Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.