Association between sulfur microbial diet and the risk of esophageal cancer: a prospective cohort study in 101,752 American adults.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-11-07 DOI:10.1186/s12937-024-01035-y

Xiaorui Ren, Li Xin, Linglong Peng, Yi Xiao, Zhihang Zhou, Haoyun Luo, Zhiyong Zhu, Qi Wei, Yahui Jiang, Hongmei He, Ling Xiang, Yaxu Wang, Yunhao Tang, Haitao Gu

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引用次数: 0

Abstract

Background: Sulfur microbial diet (SMD) is a dietary pattern closely related to the intestinal load of sulfur-metabolizing microbes in humans. Diet and microbes may play an important role in the carcinogenesis of esophagus. However, epidemiological studies on SMD and esophageal cancer (EC) risk are scarce. Here, we evaluated this association based on a large American cohort.

Methods: In the cohort of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a SMD score was calculated to evaluate participants' compliance of SMD pattern, with higher scores presenting greater adherence. Cox hazards regression model was used to explore the association between the SMD score and the incidence of EC, esophageal squamous cell carcinoma (ESCC), and esophageal adenocarcinoma (EA). Subgroup analyses were conducted to figure out potential modifiers interacting with SMD on EC. Sensitivity analyses were used to testify the robustness of our main result.

Results: Among 101,752 participants, 154 EC cases, consisted of 41 ESCC cases and 97 EA cases, were identified with mean follow-up of 8.9 years. In the fully adjusted model, the highest versus the lowest quartiles of the SMD score were found to be associated with an increased risk of EC and ESCC (EC: HR_{Q4 vs. Q1}: 1.64; 95% CI: 1.05, 2.56; P = 0.016 for trend; ESCC: HR_{Q4 vs. Q1}: 2.37; 95% CI: 1.02, 5.47; P = 0.031 for trend), while not significantly associated with increases risk of EA (HR_{Q4 vs. Q1}: 1.41; P = 0.144 for trend). The main result remained through a series of sensitivity analyses. Subgroup analyses showed a stronger association between SMD and EC in participants with no regular consumption of aspirin (HR_{Q4 vs. Q1}: 1.90; 95% CI: 1.04, 3.47) than in those using aspirin regularly (HR_{Q4 vs. Q1}: 1.37; 95% CI: 0.71, 2.66) (P = 0.008 for interaction).

Conclusion: Adherence to the SMD pattern may be associated with increased risks of EC and ESCC, particularly for EC in individuals who do not regularly consume aspirin.

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含硫微生物饮食与食道癌风险之间的关系：对 101,752 名美国成年人进行的前瞻性队列研究。

背景：硫微生物饮食（SMD）是一种与人类肠道硫代谢微生物负荷密切相关的饮食模式。饮食和微生物可能在食道癌的发生中扮演重要角色。然而，有关 SMD 和食管癌（EC）风险的流行病学研究却很少。在此，我们根据一个大型美国队列对这种关联进行了评估：方法：在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验（PLCO）的队列中，计算了 SMD 分数，以评估参与者对 SMD 模式的依从性，分数越高，依从性越高。采用Cox危害回归模型探讨了SMD评分与EC、食管鳞状细胞癌（ESCC）和食管腺癌（EA）发病率之间的关系。研究人员还进行了亚组分析，以找出与SMD对EC的影响相互影响的潜在调节因素。敏感性分析用于检验我们主要结果的稳健性：在101752名参与者中，发现了154例EC病例，其中包括41例ESCC病例和97例EA病例，平均随访时间为8.9年。在完全调整模型中，发现SMD得分最高与最低四分位数与EC和ESCC风险增加有关（EC：HRQ4 vs. Q1：1.64；95% CI：1.05, 2.56；P = 0.016）。56; P = 0.016 for trend; ESCC: HRQ4 vs. Q1: 2.37; 95% CI: 1.02, 5.47; P = 0.031 for trend)，而与 EA 风险增加无明显关联（HRQ4 vs. Q1: 1.41; P = 0.144 for trend）。通过一系列敏感性分析，主要结果依然存在。亚组分析显示，与定期服用阿司匹林的参与者（HRQ4 vs. Q1: 1.04, 3.47; 95% CI: 1.37; 95% CI: 0.71, 2.66）相比，未定期服用阿司匹林的参与者（HRQ4 vs. Q1: 1.90; 95% CI: 1.04, 3.47）的SMD与EC之间的关联性更强（P = 0.008表示交互作用）：结论：SMD模式的坚持可能与EC和ESCC风险的增加有关，尤其是对于不经常服用阿司匹林的人来说。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.