Alkaloids and Styryl Lactones from Goniothalamus tortilipetalus and Their Biological Activities.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2024-11-07 DOI:10.1021/acs.jnatprod.4c00933

Sorraya Champakam, Brian O Patrick, Natcha Injan, Somkiat Nokbin, Sarot Cheenpracha, Zi Han Loh, Tharakorn Maneerat, Panom Winyayong, Phunrawie Promnart, Siau Hui Mah, Raymond J Andersen, Surat Laphookhieo

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引用次数: 0

Abstract

Phytochemical investigations of the twig and leaf extracts of Goniothalamus tortilipetalus resulted in the isolation and identification of two new alkaloids, goniotortiline (1) and goniotortilactam (2), three new styryl lactone derivatives, goniotortilactone (3) and goniotortilols A (4) and B (5), and 25 known compounds. Their structures were elucidated by spectroscopic methods and HRESITOFMS data. Compounds 5, 13, 15, 16, 22, and 30 inhibited nitric oxide (NO) production with IC₅₀ values ranging from 8.7 ± 0.1 to 17 ± 1 μM, revealing stronger effects than the standard drug, dexamethasone (IC₅₀ 16.9 ± 2.2 μM), and compound 30 possessed the most potent NO production inhibition. Compounds 12 and 29 demonstrated notable efficacy in enhancing glucose consumption with IC₅₀ values of 77 ± 4 and 66 ± 4 μM, respectively, while their glucose uptakes were 1.7- and 2-fold, respectively.

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来自 Goniothalamus tortilipetalus 的生物碱和苯乙烯内酯及其生物活性。

通过对 Goniothalamus tortilipetalus 的树枝和叶提取物进行植物化学研究，分离并鉴定出了两种新生物碱--goniotortiline (1) 和 goniotortilactam (2)，三种新苯乙烯内酯衍生物--goniotortilactone (3) 和 goniotortilols A (4) 和 B (5)，以及 25 种已知化合物。通过光谱方法和 HRESITOFMS 数据阐明了这些化合物的结构。化合物 5、13、15、16、22 和 30 抑制了一氧化氮（NO）的产生，其 IC50 值从 8.7 ± 0.1 到 17 ± 1 μM，比标准药物地塞米松（IC50 16.9 ± 2.2 μM）的效果更强，其中化合物 30 对一氧化氮产生的抑制作用最强。化合物 12 和 29 在增强葡萄糖消耗方面具有显著疗效，IC50 值分别为 77 ± 4 和 66 ± 4 μM，而它们的葡萄糖摄取量分别为 1.7 倍和 2 倍。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.