Excessive Supplement of l-Arginine Induces Myopia via Orchestrating the MEK-ERK-NO Signaling Pathway

IF 5.7 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2024-11-13 DOI:10.1021/acs.jafc.4c09346

Bo Bao, Jinpeng Liu, Jizhao Xin, Xiangkun Zhou, Ruixue Zhang, Jiawen Hao, Zhaohui Yang, Miao Zhang, Zhongyu Ma, Xuewei Yin, Hongsheng Bi, Dadong Guo

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Abstract

Myopia can impact an individual’s quality of life and induce multiple complications. In this study, we randomly divided guinea pigs into the normal control (NC) group, the lens-induced myopia (LIM) group, the normal control plus l-arginine injection (l-Arg) group, and the normal control plus saline injection (NaCl) group. The animals in each group received the relevant treatments. The results showed that myopia was deeper in the LIM and l-Arg groups compared with the NC and NaCl groups. Our experimental results suggest that the excessive supplement of l-Arg will induce myopia onset and a MEK-ERK cascade that stimulates the downstream nNOS-MMP2 and NRF2-KEAP1 signaling pathways, which is accompanied by inflammatory responses, fibrosis changes, and oxidative stress. After receiving excessive arginine supplements, the experimental individuals showed myopic shifts and a similar pathological state as the LIM group. In conclusion, the supplement of excessive arginine may be a danger factor for myopia onset.

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过量补充精氨酸可通过协调 MEK-ERK-NO 信号通路诱发近视

近视会影响个人的生活质量并诱发多种并发症。在这项研究中，我们将豚鼠随机分为正常对照（NC）组、透镜诱发近视（LIM）组、正常对照加注射精氨酸（l-Arg）组和正常对照加注射生理盐水（NaCl）组。各组动物均接受了相关治疗。结果表明，与 NC 组和 NaCl 组相比，LIM 组和 l-Arg 组的近视度数更深。我们的实验结果表明，过量补充 l-Arg 会诱导近视发生，并引起 MEK-ERK 级联反应，刺激下游的 nNOS-MMP2 和 NRF2-KEAP1 信号通路，同时伴随炎症反应、纤维化变化和氧化应激。补充过量精氨酸后，实验者出现近视偏移，病理状态与 LIM 组相似。总之，补充过量精氨酸可能是近视发病的危险因素。

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.