Unsaturated Fatty Acids in Mental Disorders: An Umbrella Review of Meta-Analyses.

Xuping Gao, Xin Su, Xue Han, Huiyan Wen, Chen Cheng, Shiwen Zhang, Wanlin Li, Jun Cai, Lu Zheng, Junrong Ma, Minqi Liao, Wanze Ni, Tao Liu, Dan Liu, Wenjun Ma, Shasha Han, Sui Zhu, Yanbin Ye, Fang-Fang Zeng
{"title":"Unsaturated Fatty Acids in Mental Disorders: An Umbrella Review of Meta-Analyses.","authors":"Xuping Gao, Xin Su, Xue Han, Huiyan Wen, Chen Cheng, Shiwen Zhang, Wanlin Li, Jun Cai, Lu Zheng, Junrong Ma, Minqi Liao, Wanze Ni, Tao Liu, Dan Liu, Wenjun Ma, Shasha Han, Sui Zhu, Yanbin Ye, Fang-Fang Zeng","doi":"10.1093/advances/nmac084","DOIUrl":null,"url":null,"abstract":"<p><p>Unsaturated fatty acids might be involved in the prevention of and improvement in mental disorders, but the evidence on these associations has not been comprehensively assessed. This umbrella review aimed to appraise the credibility of published evidence evaluating the associations between unsaturated fatty acids and mental disorders. In this umbrella review, systematic reviews and meta-analyses of studies comparing unsaturated fatty acids (including supplementation, dietary intake, and blood concentrations) in participants with mental disorders with healthy individuals were included. We reanalyzed summary estimates, between-study heterogeneity, predictive intervals, publication bias, small-study effects, and excess significance bias for each meta-analysis. Ninety-five meta-analyses from 29 systematic reviews were included, encompassing 43 studies on supplementation interventions, 32 studies on dietary factors, and 20 studies on blood biomarkers. Suggestive evidence was only observed for dietary intake, in which higher intake of fish was associated with reduced risk of depression (RR: 0.78; 95% CI: 0.69, 0.89) and Alzheimer disease (RR: 0.74; 95% CI: 0.63, 0.87), and higher intake of total PUFAs might be associated with a lower risk of mild cognitive impairment (RR: 0.71; 95% CI: 0.61, 0.84). Evidence showed that PUFA supplementation was favorable but had weak credibility in anxiety, depression, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), dementia, mild cognitive impairment, Huntington's disease, and schizophrenia (P-random effects <0.001-0.040). There was also weak evidence on the effect of decreased circulating n-3 (ɷ-3) PUFAs among patients on risk of ADHD, ASD, bipolar disorder, and schizophrenia (P-random effects <10-6-0.037). Our results suggest that higher levels of unsaturated fatty acids may relieve symptoms or reduce the risk of various mental disorders; however, the strength of the associations and credibility of the evidence were generally weak. Future high-quality research is needed to identify whether PUFA interventions should be prioritized to alleviate mental disorders.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":"13 6","pages":"2217-2236"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776730/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in nutrition (Bethesda, Md.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/advances/nmac084","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Unsaturated fatty acids might be involved in the prevention of and improvement in mental disorders, but the evidence on these associations has not been comprehensively assessed. This umbrella review aimed to appraise the credibility of published evidence evaluating the associations between unsaturated fatty acids and mental disorders. In this umbrella review, systematic reviews and meta-analyses of studies comparing unsaturated fatty acids (including supplementation, dietary intake, and blood concentrations) in participants with mental disorders with healthy individuals were included. We reanalyzed summary estimates, between-study heterogeneity, predictive intervals, publication bias, small-study effects, and excess significance bias for each meta-analysis. Ninety-five meta-analyses from 29 systematic reviews were included, encompassing 43 studies on supplementation interventions, 32 studies on dietary factors, and 20 studies on blood biomarkers. Suggestive evidence was only observed for dietary intake, in which higher intake of fish was associated with reduced risk of depression (RR: 0.78; 95% CI: 0.69, 0.89) and Alzheimer disease (RR: 0.74; 95% CI: 0.63, 0.87), and higher intake of total PUFAs might be associated with a lower risk of mild cognitive impairment (RR: 0.71; 95% CI: 0.61, 0.84). Evidence showed that PUFA supplementation was favorable but had weak credibility in anxiety, depression, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), dementia, mild cognitive impairment, Huntington's disease, and schizophrenia (P-random effects <0.001-0.040). There was also weak evidence on the effect of decreased circulating n-3 (ɷ-3) PUFAs among patients on risk of ADHD, ASD, bipolar disorder, and schizophrenia (P-random effects <10-6-0.037). Our results suggest that higher levels of unsaturated fatty acids may relieve symptoms or reduce the risk of various mental disorders; however, the strength of the associations and credibility of the evidence were generally weak. Future high-quality research is needed to identify whether PUFA interventions should be prioritized to alleviate mental disorders.

精神障碍中的不饱和脂肪酸:荟萃分析综述》。
不饱和脂肪酸可能有助于预防和改善精神障碍,但有关这些关联的证据尚未得到全面评估。本综述旨在评估已发表的评估不饱和脂肪酸与精神障碍之间关系的证据的可信度。在本综述中,纳入了比较精神障碍患者和健康人体内不饱和脂肪酸(包括补充剂、膳食摄入量和血液浓度)的系统综述和荟萃分析研究。我们重新分析了每项荟萃分析的汇总估计值、研究间异质性、预测区间、发表偏倚、小研究效应和过度显著性偏倚。共纳入了 29 篇系统综述中的 95 项荟萃分析,包括 43 项关于补充剂干预措施的研究、32 项关于饮食因素的研究和 20 项关于血液生物标志物的研究。其中,鱼类摄入量越高,患抑郁症(RR:0.78;95% CI:0.69,0.89)和阿尔茨海默病(RR:0.74;95% CI:0.63,0.87)的风险就越低,而摄入总的 PUFAs 量越高,患轻度认知障碍(RR:0.71;95% CI:0.61,0.84)的风险就越低。证据显示,补充 PUFA 对焦虑症、抑郁症、注意力缺陷/多动障碍(ADHD)、自闭症谱系障碍(ASD)、痴呆症、轻度认知障碍、亨廷顿氏病和精神分裂症有利,但可信度较弱(P-随机效应
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信