The interhemispheric amygdala-accumbens circuit encodes negative valence in mice

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-11-08 DOI:10.1126/science.adp7520

Zhen Tian, Jiachen Song, Xuying Zhao, Yiming Zhou, Xi Chen, Qiumin Le, Feifei Wang, Lan Ma, Xing Liu

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Abstract

The structurally symmetric mammalian brain hemispheres are interconnected by commissural axons across the midline. However, the functions of interhemispheric connectivity remain largely unknown. We found that in mice, transection of the anterior commissure (AC), which connects the rostroventral forebrain, impaired avoidant behaviors. The basolateral amygdala (BLA) in the mouse projects to the contralateral nucleus accumbens (NAc) through the AC, independent of its ipsilateral projections. Aversive stimuli activated contralateral BLA-NAc projections. Positive stimuli, however, activated ipsilateral projections. Selective activation of contralateral BLA-NAc projections activated D2-positive medium spiny neurons (D2-MSNs), reduced NAc dopamine levels, and caused aversion, whereas selective activation of ipsilateral BLA-NAc projections activated D1-MSNs, increased NAc dopamine levels, and induced reward. The contralateral BLA-AC-NAc pathway is crucial for encoding negative valence, demonstrating distinct functions of intra- and interhemispheric circuits in brain physiology.

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小鼠大脑半球间杏仁核--阿克伦脑回路编码负性情感

哺乳动物的大脑半球在结构上是对称的，通过神经轴突跨越中线相互连接。然而，半球间连接的功能在很大程度上仍然未知。我们发现，在小鼠身上，切断连接喙突前脑的前裂（AC）会损害回避行为。小鼠的基底外侧杏仁核（BLA）通过 AC 投射到对侧伏隔核（NAc），与其同侧的投射无关。逆反刺激激活了对侧杏仁核-NAc的投射。然而，阳性刺激会激活同侧投射。选择性激活对侧 BLA-NAc 递呈可激活 D2 阳性中刺神经元（D2-MSNs），降低 NAc 多巴胺水平并导致厌恶，而选择性激活同侧 BLA-NAc 递呈可激活 D1-MSNs，增加 NAc 多巴胺水平并诱发奖赏。对侧的BLA-AC-NAc通路对编码负价至关重要，这表明大脑半球内和半球间回路在大脑生理学中具有不同的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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