Hyperkeratosis in Skin Dimples in Children With Down Syndrome.

IF 1.2 4区医学 Q3 DERMATOLOGY

Pediatric Dermatology Pub Date : 2025-03-01 Epub Date: 2024-11-06 DOI:10.1111/pde.15813

Susana Giraldi, Betina Werner, Mariana Aparecida Pasa Morgan, Antonio Torrelo

引用次数: 0

Abstract

Down syndrome (DS) is a common chromosomal disorder with distinct phenotypes and skin markers. This study reports 39 DS patients, aged 1-44 months, who presented from birth with rough, brownish skin in the dimples of their knees and/or elbows. Dermoscopy revealed hyperkeratosis with brownish scales, and biopsies in six cases showed papillomatosis and mild hyperkeratosis. In the cases followed, the condition resolved spontaneously. Hyperkeratosis in the skin dimples on the knees and elbows seems to be a congenital and perhaps characteristic finding in patients with DS.

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唐氏综合征患儿皮肤丘疹角化过度。

唐氏综合征（DS）是一种常见的染色体疾病，具有不同的表型和皮肤标记。本研究报告了 39 名 1-44 个月大的唐氏综合征患者，他们从出生起就出现膝盖和/或肘部凹陷处皮肤粗糙、呈褐色的症状。皮肤镜检查发现皮肤角化过度并伴有褐色鳞屑，6 例患者的活检结果显示患有乳头状瘤病和轻度角化过度。在随访的病例中，病情自行缓解。膝盖和肘部皮肤凹陷处的过度角化似乎是 DS 患者的先天性特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.