The association between dietary consumption habits and psoriasis: a two-sample Mendelian randomization study.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1405663

Lu Minghui, Gao Changyong, Zhang Runtian, Li Jianhong, Yuan Lingling, Chen Xi

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引用次数: 0

Abstract

Background: Psoriasis is a chronic inflammatory skin disease characterized primarily by erythema and scales, having a wide-ranging impact globally. Previous studies have suggested that dietary consumption habits may influence psoriasis. The objective of this study was to determine the causal relationship between dietary consumption habits and psoriasis using the Mendelian Randomization (MR) approach.

Methods: SNP data for 29 dietary consumption habits and psoriasis were obtained from the GWAS catalog database and the FinnGen database, respectively. The Mendelian Randomization analysis was performed using R software, with the 29 dietary consumption habits as the exposure factors and psoriasis as the outcome. Three MR analysis methods-Inverse Variance Weighted (IVW), Weighted Median Estimator (WME), and MR-Egger regression-were employed to study the causal relationship between dietary consumption habits and psoriasis.

Results: The IVW analysis indicated an OR (95%CI) of 0.065 (0.008-0.555), p = 0.012, demonstrating a negative correlation between the consumption of dried fruit and psoriasis.

Conclusion: Among the 29 dietary consumption habits analyzed, the intake of dried fruits is a protective factor against psoriasis. Therefore, it is clinically advisable to appropriately increase the intake of dried fruits among patients with psoriasis, serving as a nutritional therapy method in conjunction with pharmacological treatment.

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饮食消费习惯与银屑病的关系：双样本孟德尔随机研究。

背景：银屑病是一种以红斑和鳞屑为主要特征的慢性炎症性皮肤病，在全球范围内影响广泛。以往的研究表明，饮食消费习惯可能会影响银屑病。本研究的目的是利用孟德尔随机化（MR）方法确定饮食消费习惯与银屑病之间的因果关系：29种饮食消费习惯和银屑病的SNP数据分别来自GWAS目录数据库和FinnGen数据库。使用 R 软件进行孟德尔随机分析，以 29 种饮食消费习惯为暴露因子，以银屑病为结果。采用三种MR分析方法--逆方差加权法（IVW）、加权中位估计法（WME）和MR-Egger回归法，研究饮食消费习惯与银屑病之间的因果关系：IVW分析表明，OR（95%CI）为0.065（0.008-0.555），P = 0.012，表明食用干果与银屑病之间存在负相关：结论：在分析的 29 种饮食消费习惯中，干果的摄入量是银屑病的一个保护因素。因此，临床上建议银屑病患者适当增加干果的摄入量，作为与药物治疗相结合的营养治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.