Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.

IF 2.1 4区 医学 Q2 PSYCHOLOGY, CLINICAL
Sanjiv Kale, Adrian Lopresti, Ravleen Suri, Neha Garg, Deepak Langade
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Abstract

This prospective, randomized, placebo-controlled study assessed the effects of Ashwagandha root extract (ARE) on cognition, energy, and mood in adults with self-reported cognitive and energy problems. Healthy subjects aged 30-75 years were randomized to receive ashwagandha (Withania somnifera) root extract (ARE) 600 mg/day (n = 60)/identical placebo (n = 60) orally for 8 weeks. Cognitive function was assessed at baseline and week 8 using a Computerized Mental Performance Assessment System (COMPASS). Secondary outcomes were Profile of Mood States Abbreviated Version (POMS-A), Mental Fatigue Scale (MFS) and Behavior Rating Inventory of Executive Function-Adult (BRIEF-A) for effects on mood, mental fatigue and executive function, respectively, assessed at baseline, week 4 and 8. Greater improvement (p < .05) from baseline scores were seen with ARE as against placebo for COMPASS items episodic memory, working memory and accuracy of attention. ARE also improved the POMS-A, MFS and BRIEF-A scores from baseline suggesting an improvement in mood, vigor, and an increase in the executive functioning respectively with ARE. The herb was well tolerated and had a good patient compliance with no serious adverse events reported in either of the groups. This study suggests that a dose of 600 mg a day can improve cognition, energy, and mood in adults with self-reported cognitive and energy problems.

芦根提取物对成人认知、能量和情绪问题的安全性和有效性:前瞻性、随机、安慰剂对照研究。
这项前瞻性、随机、安慰剂对照研究评估了芦根提取物(ARE)对自我报告有认知和精力问题的成年人的认知、精力和情绪的影响。年龄在 30-75 岁之间的健康受试者随机接受芦根提取物(ARE)600 毫克/天(n = 60)/同种安慰剂(n = 60)口服,为期 8 周。认知功能在基线和第 8 周使用计算机化智力表现评估系统 (COMPASS) 进行评估。次要结果为情绪状态简易版(POMS-A)、精神疲劳量表(MFS)和执行功能行为评定量表-成人(BRIEF-A),分别用于评估在基线、第 4 周和第 8 周对情绪、精神疲劳和执行功能的影响。改善幅度更大(p
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来源期刊
CiteScore
5.30
自引率
7.10%
发文量
62
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