Kaposi Sarcoma in the Context of Post-Modified Radical Mastectomy: A New Case Report and Brief Review.

IF 1.6 4区 医学 Q3 DERMATOLOGY
Rasha Mahmoud Genedy, Naglaa Mohamed El Sayed
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引用次数: 0

Abstract

Kaposi sarcoma is a human herpesvirus 8-associated angio-proliferative tumor arising from lymphatic endothelial cells. Four clinical subtypes are known: classic, epidemic, endemic, and iatrogenic. The development of Kaposi sarcoma and lymphedema may be interlinked, where each condition could potentially support the progression of the other. Post-mastectomy lymphedema is a commonly recognized complication following radical mastectomy. Angiosarcoma is the most frequently reported neoplasm in such a situation. We present a 72-year-old female who developed Kaposi sarcoma on the same side of mastectomy 9 years following her initial diagnosis and treatment for cancer breast. The diagnosis of Kaposi sarcoma was based on the histopathologic findings and was confirmed with immunohistochemical staining for human herpes virus 8 and D2-40. Lymphedema may be associated with local immune suppression manifested in the form of defective cell-mediated immunity and antigen-presenting cell migration defect which may facilitate development of neoplasms. It is important to differentiate Kaposi sarcoma from other vascular tumors which may have a much worse prognosis. Patients with lymphedema should receive appropriate management and undergo long-term follow-up for early detection of any potential malignancies.

改良根治性乳房切除术后的卡波西肉瘤:新病例报告和简要回顾。
卡波西肉瘤是一种与人类疱疹病毒 8 相关的血管增生性肿瘤,产生于淋巴内皮细胞。目前已知有四种临床亚型:典型型、流行型、地方性型和先天性型。卡波西肉瘤和淋巴水肿的发展可能是相互关联的,每种情况都有可能促进另一种情况的发展。乳房切除术后淋巴水肿是根治性乳房切除术后常见的并发症。在这种情况下,血管肉瘤是最常见的肿瘤。我们介绍了一名 72 岁的女性,她在初次诊断和治疗乳腺癌 9 年后,在乳房切除术的同侧患上了卡波西肉瘤。卡波西肉瘤的诊断是基于组织病理学结果,并通过人类疱疹病毒 8 和 D2-40 的免疫组化染色得到证实。淋巴水肿可能与局部免疫抑制有关,表现为细胞介导免疫缺陷和抗原递呈细胞迁移缺陷,这可能会促进肿瘤的发展。重要的是要将卡波西肉瘤与其他预后可能更差的血管肿瘤区分开来。淋巴水肿患者应接受适当的治疗和长期随访,以便及早发现任何潜在的恶性肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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