Cognitive impairment and amygdala subregion volumes in elderly with cerebral small vessel disease: A large prospective cohort study

IF 5.1 2区医学 Q1 NEUROSCIENCES

Neurobiology of Disease Pub Date : 2024-11-01 DOI:10.1016/j.nbd.2024.106716

Zhenyu Cheng , Linfeng Yang , Jing Li , Yiwen Chen , Pengcheng Liang , Yuanyuan Wang , Na Wang , Xinyue Zhang , Yian Gao , Chaofan Sui , Meng Li , Changhu Liang , Lingfei Guo

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引用次数: 0

Abstract

Although the amygdala is associated with cognitive impairment resulting from cerebral small vessel disease, the relationship between alterations in amygdala structure and cerebral small vessel disease (CSVD) remains controversial. Given that the amygdala comprises several subregions, detecting subtle regional changes through total amygdala volume measurement is challenging. This study aimed to identify the patterns of amygdala subregion atrophy in cerebral small vessel disease patients and their relationship with cognitive impairment. A total of 114 participants diagnosed with cerebral small vessel disease and 129 healthy participants, aged 40 to 70, underwent 3 T magnetic resonance imaging scans. The amygdala subregions were automatically segmented using FreeSurfer. In the Propensity Score Matching (PSM)-matched cohort, Lasso regression was employed to identify subregions associated with cerebral small vessel disease, and restricted cubic splines (RCS) were used to explore their nonlinear relationship with cognitive abilities. Subsequently, multivariate linear regression models were used to investigate the impact of amygdala subregion volumes on various cognitive abilities. Compared to healthy controls (HC), the volume of the left cortical nucleus was significantly reduced in cerebral small vessel disease patients. The volume of the left cortical nucleus was significantly negatively correlated with cerebral small vessel disease progression, and atrophy in this region was also identified as an independent risk factor for decreased cognitive control and processing ability. Our findings suggest that patients with cerebral small vessel disease exhibit atrophy in specific amygdala subregions compared to healthy controls, which correlates with poorer cognitive control and processing abilities. These insights may advance our understanding of the pathogenesis of cerebral small vessel disease.

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患有脑小血管疾病的老年人的认知障碍和杏仁核亚区体积：一项大型前瞻性队列研究

尽管杏仁核与脑小血管疾病导致的认知障碍有关，但杏仁核结构的改变与脑小血管疾病（CSVD）之间的关系仍存在争议。鉴于杏仁核由多个亚区组成，通过测量杏仁核的总体积来检测细微的区域变化具有挑战性。本研究旨在确定脑小血管疾病患者杏仁核亚区萎缩的模式及其与认知障碍的关系。共有114名确诊为脑小血管疾病的患者和129名年龄在40至70岁之间的健康患者接受了3 T磁共振成像扫描。研究人员使用 FreeSurfer 自动分割杏仁核亚区。在倾向评分匹配（PSM）组群中，采用拉索回归（Lasso regression）来识别与脑小血管疾病相关的亚区，并采用受限立方样条（RCS）来探索它们与认知能力的非线性关系。随后，采用多变量线性回归模型研究了杏仁核亚区体积对各种认知能力的影响。与健康对照组（HC）相比，脑小血管疾病患者的左侧皮质核体积明显缩小。左侧皮质核的体积与大脑小血管疾病的进展呈显著负相关，该区域的萎缩也被确定为认知控制和处理能力下降的独立风险因素。我们的研究结果表明，与健康对照组相比，脑小血管疾病患者表现出特定杏仁核亚区的萎缩，这与较差的认知控制和处理能力有关。这些发现可能会促进我们对脑小血管疾病发病机制的了解。

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来源期刊

Neurobiology of Disease 医学-神经科学

CiteScore

11.20

自引率

3.30%

发文量

270

审稿时长

76 days

期刊介绍： Neurobiology of Disease is a major international journal at the interface between basic and clinical neuroscience. The journal provides a forum for the publication of top quality research papers on: molecular and cellular definitions of disease mechanisms, the neural systems and underpinning behavioral disorders, the genetics of inherited neurological and psychiatric diseases, nervous system aging, and findings relevant to the development of new therapies.