Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy.

IF 5 2区 医学 Q1 OPHTHALMOLOGY
Juan Zhang, Lu Ruan, Chen Jiang, Qian Yang, Qing Chang, Xin Huang
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Abstract

Purpose: To investigate microvascular growth defects in the temporal midperipheral retina and their correlations with vitreoretinal microstructural abnormalities (VRMAs) in early-stage familial exudative vitreoretinopathy (FEVR).

Methods: We enrolled 127 patients (127 eyes) with early-stage FEVR and 31 healthy subjects (31 eyes). Widefield optical coherence tomography angiography was conducted for all enrolled eyes. Vessel density (VD), vessel diameter index (VDI), and vessel index (VI; VD/VDI) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in temporal midperiphery were further evaluated. The distance from the vessel sprouting point of the optic disc to the avascular area margin (Optic-AVA) was measured to assess retinal vascular dysplasia.

Results: In early-stage FEVR, 61.42% of eyes showed retinal microvascular abnormalities (MVAs) in the temporal midperiphery, all combined with VRMAs. Common MVAs presented disordered vascular anastomoses in the SCP and capillary loss in the DCP, corresponding to deficient neuroretina. The preretinal vasculature (PRV) was detected in 36 eyes. VD and VI were lower in FEVR eyes compared to controls, whereas the VDI in the SCP was larger (all P < 0.001). Optic-AVA was positively correlated with VD and VI in both plexuses and negatively correlated with the VDI in the SCP. PRV existence was independently correlated with decreased VI in the DCP (odds ratio [OR] = 0.322; P < 0.001), and VRMA existence was independently correlated with decreased VI in SCP and DCP (SCP OR = 0.282, P = 0.010; DCP OR = 0.562, P = 0.002).

Conclusions: MVAs in the temporal midperipheral retina were revealed. Microvascular loss may be correlated with Optic-AVA reduction, PRV, and the presence of VRMAs.

早期家族性渗出性玻璃体视网膜病变的中周微血管缺陷及其与玻璃体视网膜异常的关系
目的:研究早期家族性渗出性玻璃体视网膜病变(FEVR)患者颞中周视网膜微血管生长缺陷及其与玻璃体视网膜微结构异常(VRMA)的相关性:我们招募了 127 名早期 FEVR 患者(127 只眼)和 31 名健康受试者(31 只眼)。对所有入组眼睛进行了宽视场光学相干断层血管造影。进一步评估了颞中周浅毛细血管丛(SCP)和深毛细血管丛(DCP)的血管密度(VD)、血管直径指数(VDI)和血管指数(VI;VD/VDI)。测量视盘血管萌发点到无血管区边缘(Optic-AVA)的距离,以评估视网膜血管发育不良的情况:结果:在早期 FEVR 中,61.42% 的眼睛在颞中周出现视网膜微血管异常(MVA),所有这些都合并有 VRMA。常见的 MVAs 表现为 SCP 的血管吻合紊乱和 DCP 的毛细血管缺失,与神经视网膜缺失相对应。36 只眼睛检测到了视网膜前血管(PRV)。与对照组相比,FEVR 眼睛的 VD 和 VI 更低,而 SCP 的 VDI 更大(所有 P <0.001)。视神经AVA与两个神经丛的VD和VI呈正相关,而与SCP的VDI呈负相关。PRV的存在与DCP的VI下降独立相关(几率比[OR] = 0.322;P < 0.001),VRMA的存在与SCP和DCP的VI下降独立相关(SCP OR = 0.282,P = 0.010;DCP OR = 0.562,P = 0.002):结论:颞叶中周视网膜的 MVAs 被发现。微血管缺失可能与视网膜AVA减少、PRV和VRMA的存在有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
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