Fluoride stimulates the MAPK pathway to regulate endoplasmic reticulum stress and heat shock proteins to induce duodenal toxicity in chickens.

IF 3.8 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Poultry Science Pub Date : 2024-10-10 DOI:10.1016/j.psj.2024.104408

Yanan Li, Tianwen Ma, Xiaoping Lv, Zongsheng Qiu, Shuxin Li, Jingjing Qi, Chengwei Wei

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引用次数: 0

Abstract

Fluoride is one of the essential trace elements for body. However, excessive fluoride poses a major threat to human and animal health. Fluorosis may cause pathological damage of the duodenum, but the underlying mechanism needs to be further studied. This study was to investigate the effects of long-term exposure to sodium fluoride (0, 500, 1,000, 2,000 mg/kg) on the duodenum of chickens. The results showed that after NaF exposure, intestinal epithelial cells were disarranged, necrotic or even exfoliated, goblet cells and mucus secretion were increased, and inflammatory response was induced in duodenal tissue. Oxidative stress, endoplasmic reticulum stress (ERs), and heat shock proteins (HSPs) are an adaptive response, however long-term, excessive changes are detrimental. Fluorosis activates ERs through IRE1, PERK and ATF6 pathways, increases the expression of HSP60, HSP70 and HSP90, and causes apoptosis and oxidative damage in duodenal tissue. In addition, fluorosis can activate the MAPK signaling pathway. This article can provide a reference for exploring the potential duodenal toxicity of sodium fluoride.

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氟化物刺激 MAPK 通路，调节内质网应激和热休克蛋白，诱发鸡十二指肠中毒。

氟是人体必需的微量元素之一。然而，过量的氟对人类和动物的健康构成了重大威胁。氟中毒可能导致十二指肠的病理损伤，但其潜在机制有待进一步研究。本研究旨在探讨长期接触氟化钠（0、500、1,000、2,000 毫克/千克）对鸡十二指肠的影响。结果表明，接触氟化钠后，肠上皮细胞变异、坏死甚至脱落，鹅口疮细胞和粘液分泌增加，十二指肠组织出现炎症反应。氧化应激、内质网应激（ERs）和热休克蛋白（HSPs）是一种适应性反应，但长期、过度的变化是有害的。氟中毒会通过 IRE1、PERK 和 ATF6 途径激活 ER，增加 HSP60、HSP70 和 HSP90 的表达，并导致十二指肠组织凋亡和氧化损伤。此外，氟中毒还能激活 MAPK 信号通路。本文可为探讨氟化钠潜在的十二指肠毒性提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Poultry Science 农林科学-奶制品与动物科学

CiteScore

7.60

自引率

15.90%

发文量

审稿时长

94 days

期刊介绍： First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across all disciplines. As of January 2020, Poultry Science will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers. An international journal, Poultry Science publishes original papers, research notes, symposium papers, and reviews of basic science as applied to poultry. This authoritative source of poultry information is consistently ranked by ISI Impact Factor as one of the top 10 agriculture, dairy and animal science journals to deliver high-caliber research. Currently it is the highest-ranked (by Impact Factor and Eigenfactor) journal dedicated to publishing poultry research. Subject areas include breeding, genetics, education, production, management, environment, health, behavior, welfare, immunology, molecular biology, metabolism, nutrition, physiology, reproduction, processing, and products.