A Wearable Electrochemical Sensor Based on Single-Atom Pt Anchored on Activated NiCo-LDH/Ti3C2Tx for Real-Time Monitoring of Glucose.

Abstract

Wearable, noninvasive sweat sensors enable real-time monitoring of metabolites in human health management. However, the commercial enzyme-based and currently nonenzymatic glucose sensor represents sluggish glucose oxidation kinetics and a narrow sensing range. Rational design of sensitive materials is significant yet faces a huge challenge. Herein, we construct a single-atom Pt supported on NiCo-LDH/Ti₃C₂T_x heterostructures (Pt₁-NiCo-LDH/Ti₃C₂T_x) as the nonenzymatic electrochemical glucose sensor sensitive materials for selective detection of glucose level in human sweat. The obtained Pt₁-NiCo-LDH/Ti₃C₂T_x with improved structural stability and enhanced charge transfer efficiency shows a low oxidation peak potential of 0.49 V, high sensitivity of 506.6 μA mM^-1 cm^-2, a low detection limit of 0.035 μM, and long-term stability toward the glucose detection. The wearable sensor, coupled with a wireless transmission module and a signal processing chip, is used for real-time perspiration glucose monitoring during outdoor exercise. The result is comparable to that of high-performance liquid chromatography (HPLC). This research provides a new paradigm for designing a wearable nonenzymatic electrochemical glucose sensor, enabling noninvasive real-time monitoring of glucose concentrations in human sweat.