Decreased diaphragm moving distance measured by ultrasound speckle tracking reflects poor prognosis in amyotrophic lateral sclerosis

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2024-01-01 DOI:10.1016/j.cnp.2024.10.002

Shunsuke Watanabe , Kenji Sekiguchi , Hirotomo Suehiro , Masaaki Yoshikawa , Yoshikatsu Noda , Naohisa Kamiyama , Riki Matsumoto

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引用次数: 0

Abstract

Objective

Decreased cephalocaudal diaphragm movement may indicate respiratory dysfunction in amyotrophic lateral sclerosis (ALS). We aimed to evaluate diaphragm function in ALS using ultrasound speckle tracking, an image-analysis technology that follows similar pixel patterns.

Methods

We developed an offline application that tracks pixel patterns of recorded ultrasound video images using speckle-tracking methods. Ultrasonography of the diaphragm movement during spontaneous quiet respiration was performed on 19 ALS patients and 21 controls to measure the diaphragm moving distance (DMD) in the cephalocaudal direction during a single respiration. We compared respiratory function measures and analyzed the relationship between the clinical profiles and DMD.

Results

DMD was significantly lower in ALS patients than in the control group (0.6 ± 1.4 mm vs 2.2 ± 2.2 mm, p < 0.01) and positively correlated with phrenic nerve compound motor action potential amplitude (R = 0.63, p = 0.01). DMD was negatively correlated with the change in the ALS Functional Rating Scale-Revised scores per month after the exam (R = −0.61, p = 0.02), and those with a larger rate of decline had a significantly lower DMD (p = 0.03).

Conclusions

Diaphragm ultrasound speckle tracking enabled the detection of diaphragm dysfunction in ALS.

Significance

Diaphragm ultrasound speckle tracking may be useful for predicting prognosis.

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超声斑点追踪技术测量的膈肌移动距离减少反映了肌萎缩侧索硬化症的不良预后

目的头尾膈肌运动减少可能预示着肌萎缩侧索硬化症（ALS）患者的呼吸功能障碍。我们的目的是利用超声斑点追踪技术评估 ALS 的膈肌功能，该技术是一种图像分析技术，可跟踪类似的像素模式。方法我们开发了一种离线应用程序，可利用斑点追踪方法跟踪记录的超声视频图像的像素模式。我们对 19 名 ALS 患者和 21 名对照组患者进行了自发安静呼吸时横膈膜运动的超声波成像，以测量单次呼吸时横膈膜在头尾方向的移动距离 (DMD)。结果 ALS 患者的膈肌移动距离明显低于对照组（0.6 ± 1.4 mm vs 2.2 ± 2.2 mm，p < 0.01），且与膈神经复合运动动作电位振幅呈正相关（R = 0.63，p = 0.01）。DMD与检查后每月ALS功能评定量表-修订版评分的变化呈负相关（R = -0.61，p = 0.02），下降率较大者的DMD显著较低（p = 0.03）。结论膈肌超声斑点追踪技术可检测ALS患者的膈肌功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.