Revisiting the Concepts of Prebiotic and Prebiotic Effect in Light of Scientific and Regulatory Progress—A Consensus Paper From the Global Prebiotic Association

IF 8 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition Pub Date : 2024-10-29 DOI:10.1016/j.advnut.2024.100329

Edward C Deehan , Santa Al Antwan , Rhonda S Witwer , Paula Guerra , Tania John , Len Monheit

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引用次数: 0

Abstract

The term prebiotic has been used for almost 3 decades and has undergone numerous updates over the years. The scientific literature reveals that despite continuous efforts to establish a globally unified definition to guide jurisdictional regulations and product innovations, ambiguity continues to surround the terms prebiotic and prebiotic effect, leading to products that lack in full regulatory adherence being marketed worldwide. Thus, to reflect the current state of scientific research and knowledge and for the continuous advancement of the category, an update to the current prebiotic definition is warranted. This update includes removing the term selectivity, considering additional locations of action besides the gut, highlighting prebiotic performance benefits such as cognitive and athletic, and providing a clear standalone definition for prebiotic effect. The Global Prebiotic Association (GPA) is a leading information and industry hub committed to raising awareness about prebiotics, their emerging and well-established health benefits, and prebiotic product integrity and efficacy. In this position paper, GPA builds on previous prebiotic definitions to propose the following expanded definition for prebiotic: “a compound or ingredient that is utilized by the microbiota producing a health or performance benefit.” In addition to prebiotic, GPA also defines prebiotic effect as “a health or performance benefit that arises from alteration of the composition and/or activity of the microbiota, as a direct or indirect result of the utilization of a specific and well-defined compound or ingredient by microorganisms.” With these 2 definitions, GPA aims to paint a clearer picture for the term prebiotic, and by incorporating an industry point of view, these updated definitions may be used alongside current scientific and regulatory perspectives to move the category forward.

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透视：根据科学和监管进展重新审视益生菌和益生菌效应的概念--全球益生菌协会 (GPA) 的共识文件。

益生菌一词已使用了近三十年，多年来经历了多次更新。科学文献显示，尽管人们一直在努力建立一个全球统一的定义，以指导辖区监管和产品创新，但益生元和益生元效应这两个术语仍然含糊不清，导致一些不完全符合监管要求的产品在全球范围内销售。因此，为了反映科学研究和知识的现状，并促进该类别的不断发展，有必要对当前的益生菌定义进行更新。更新内容包括删除选择性一词，考虑除肠道外的其他作用部位，强调益生元在认知和运动等方面的功效，并为益生元效应提供明确的独立定义。全球益生元协会（GPA）是一个领先的信息和行业中心，致力于提高人们对益生元、益生元对健康的新兴和公认益处以及益生元产品完整性和功效的认识。在本立场文件中，GPA 以以前的益生元定义为基础，提出了益生元的以下扩展定义："被微生物群利用，产生健康或性能益处的化合物或成分"。除益生元外，GPA 还将益生元效应定义为"由于微生物利用特定和明确定义的化合物或成分而直接或间接改变微生物群的组成和/或活性，从而产生的健康或性能益处"。通过这两个定义，GPA 旨在更清晰地描述益生菌这一术语，并通过纳入行业观点，将这些更新的定义与当前的科学和监管观点结合起来，推动益生菌类别的发展。意义说明：本文旨在通过提供基于科学的行业观点，重新审视益生菌和益生效应的概念。在国际益生菌和益生元科学协会（ISAPP）2017 年发布益生菌定义之后，本文提出的益生菌和益生元效应定义反映了元基因组学和益生元研究的最新发现，并提出了及时和必要的术语变更。这些修改旨在保持益生菌定义对科学界、产业界、医疗保健提供者和消费者的清晰性和实用性，同时确保益生菌定义各部分的科学性、全面性和合理性，包括放弃选择性一词，引入性能益处和益生菌效果的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Nutrition 医学-营养学

CiteScore

17.40

自引率

2.20%

发文量

117

审稿时长

56 days

期刊介绍： Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.