Bacteria divide to conquer antibiotics

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-10-31 DOI:10.1126/science.adt0042

Ewan Harrison

引用次数: 0

Abstract

Antibiotics are a cornerstone of modern medicine, and consequently, antibiotic resistance is a serious public health threat to treating bacterial infections. Shortly after penicillin came into clinical use to treat Staphylococcus aureus—a pathogen that can cause mild to fatal infections—strains resistant to the drug emerged. In 1959, the antibiotic methicillin was introduced to treat penicillin-resistant strains of S. aureus. Methicillin is a member of the β-lactam family of antibiotics that are broadly effective against many types of bacteria. However, by 1960, infections with methicillin-resistant S. aureus (MRSA) had been reported (1). Given the importance of β-lactams for treating S. aureus infections, researchers have sought to understand the mechanism and evolutionary origins of this resistance. On page 573 of this issue, Adedeji-Olulana et al. (2) report that high-level resistance to methicillin requires S. aureus to use a distinct form of cell division to ensure its survival.

查看原文本刊更多论文

细菌分裂征服抗生素

对甲氧西林的高度抗药性需要一种独特的细胞分裂形式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

期刊介绍： Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science serves as a forum for discussion of important issues related to the advancement of science by publishing material on which a consensus has been reached as well as including the presentation of minority or conflicting points of view. Accordingly, all articles published in Science—including editorials, news and comment, and book reviews—are signed and reflect the individual views of the authors and not official points of view adopted by AAAS or the institutions with which the authors are affiliated. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. They should merit recognition by the wider scientific community and general public provided by publication in Science, beyond that provided by specialty journals. Science welcomes submissions from all fields of science and from any source. The editors are committed to the prompt evaluation and publication of submitted papers while upholding high standards that support reproducibility of published research. Science is published weekly; selected papers are published online ahead of print.