Exposure to sugar rationing in the first 1000 days of life protected against chronic disease

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-10-31 DOI:10.1126/science.adn5421

Tadeja Gracner, Claire Boone, Paul J. Gertler

引用次数: 0

Abstract

We examined the impact of sugar exposure within 1000 days since conception on diabetes and hypertension, leveraging quasi-experimental variation from the end of the United Kingdom’s sugar rationing in September 1953. Rationing restricted sugar intake to levels within current dietary guidelines, yet consumption nearly doubled immediately post-rationing. Using an event study design with UK Biobank data comparing adults conceived just before or after rationing ended, we found that early-life rationing reduced diabetes and hypertension risk by about 35% and 20%, respectively, and delayed disease onset by 4 and 2 years. Protection was evident with in-utero exposure and increased with postnatal sugar restriction, especially after six months when solid foods likely began. In-utero sugar rationing alone accounted for about one third of the risk reduction.

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出生后最初 1000 天内接触糖配给可预防慢性疾病

我们利用英国 1953 年 9 月结束食糖配给后的准实验数据，研究了受孕 1000 天内摄入糖分对糖尿病和高血压的影响。配给制将糖的摄入量限制在现行膳食指南规定的范围内，但配给制结束后，糖的消费量立即增加了近一倍。我们利用英国生物库数据进行了一项事件研究设计，比较了配给结束前或配给结束后受孕的成年人，发现早期配给分别降低了约 35% 和 20% 的糖尿病和高血压风险，并将发病时间分别推迟了 4 年和 2 年。这种保护作用在胎儿时期就很明显，并随着出生后的限糖而增加，尤其是在六个月后开始吃固体食物时。仅胎内糖分配给就降低了约三分之一的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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