The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-10-28 DOI:10.1016/j.arr.2024.102555

Calvin D. Brooks , Raghu R. Krishnamoorthy , Nathalie Sumien

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引用次数: 0

Abstract

Large retrospective cohort studies have consistently shown that people who exercise regularly are at a markedly reduced risk of dementias such as Alzheimer’s Disease (AD). Animal studies have also found that exercise can prevent cognitive decline, and recent studies have identified possible mechanisms. However, randomized controlled trials of exercise interventions in AD and mild cognitive impairment have not reached a consensus regarding the efficacy of this treatment, hampering clinical adoption of this technique. This review examines these randomized controlled trials to assess potential causes for the variability in the measured outcomes. We posit that great variance in the methods used in these studies may account for some of the differences seen in outcomes. We determined that aerobic exercise led to the most benefits, that many cognitive domains improve with exercise, and that aerobic exercise enhances the ability for independent living. However, cognitive improvements were more pronounced and consistent in patients with mild cognitive impairment than AD, suggesting a narrow window of opportunity for exercise intervention.

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运动在预防和治疗阿尔茨海默病及轻度认知障碍中的作用

大型回顾性队列研究一致表明，经常锻炼的人患阿尔茨海默病（AD）等痴呆症的风险明显降低。动物实验也发现，运动可以预防认知能力下降，最近的研究还发现了可能的机制。然而，针对运动干预老年痴呆症和轻度认知障碍的随机对照试验尚未就这种疗法的疗效达成共识，从而阻碍了这种技术在临床上的应用。本综述对这些随机对照试验进行了研究，以评估造成测量结果差异的潜在原因。我们认为，这些研究中所用方法的巨大差异可能是造成结果差异的部分原因。我们认为，有氧运动带来的益处最大，许多认知领域都能通过运动得到改善，有氧运动还能提高独立生活的能力。然而，与注意力缺失症相比，轻度认知障碍患者的认知能力改善更为明显和持续，这表明运动干预的机会之窗很狭窄。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.