Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life

IF 4.5 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Laura Sáez-Fuertes, Karla Rio-Aige, Malén Massot-Cladera, Margarida Castell, Karen Knipping, Johan Garssen, Raphaëlle Bourdet-Sicard, María José Rodríguez-Lagunas, María Carmen Collado, Francisco José Pérez-Cano
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Abstract

The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn's ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M-16 V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups' plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune-related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup's diarrhea caused by the RV infection by improving their immunity.

Abstract Image

给母体补充双歧杆菌 M-16 V 和 scGOS/lcFOS 可改善婴儿早期的轮状病毒感染。
新生儿的免疫系统发育不全,很容易受到轮状病毒(RV)等感染。尽管接种了疫苗,但轮状病毒仍然是导致儿童死亡的主要原因,尤其是在发展中国家。母体免疫力会在怀孕和哺乳期间传递给后代,从而保护其免受轮状病毒感染。本研究旨在探索母体饮食如何增强新生儿抵抗早期感染的能力。怀孕大鼠口服双歧杆菌 M-16 V 和短链半乳糖寡糖(scGOS)/长链果寡糖(lcFOS)。幼崽出生后第 5 天感染 RV,第 8 天采集样本进行感染分析。母亲服用合生元的幼鼠感染 RV 的严重程度较低。幼犬血浆和消化奶中的免疫球蛋白(Ig)IgG2c 和 IgA 水平分别有所提高。补充益生菌可改善肠道成熟度,增加免疫相关基因的表达。总之,给妊娠期和哺乳期的母亲服用这种合成益生菌,可以通过提高她们的免疫力来改善幼崽因 RV 感染引起的腹泻的发生率和严重程度。
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来源期刊
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research 工程技术-食品科技
CiteScore
8.70
自引率
1.90%
发文量
250
审稿时长
1.7 months
期刊介绍: Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.
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