Three Days of Oral Azithromycin Versus Five Days of Oral Clarithromycin in the Treatment of Campylobacter Enterocolitis in Children: A Prospective Study.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

Antibiotics-Basel Pub Date : 2024-10-14 DOI:10.3390/antibiotics13100969

Hyun Mi Kang, Yoon Kyung Cho, Ye Ji Kim, Dae Chul Jeong, In Hyuk Yoo

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Abstract

Objective: This study aimed to compare the efficacy and tolerability of azithromycin and clarithromycin in pediatric Campylobacter enterocolitis.

Methods: A prospective, randomized, controlled trial was conducted at a single center. Patients with confirmed Campylobacter enterocolitis were randomly assigned to receive either a 3-day course of azithromycin or a 5-day course of clarithromycin. Symptoms were monitored daily, and changes in laboratory markers (WBC counts, CRP levels, and stool calprotectin) were compared.

Results: A total of 29 pediatric patients were included, with 14 patients in the azithromycin group and 15 patients in the clarithromycin group. The median age of patients in the azithromycin group was 10.0 years (interquartile range [IQR]: 5.0-13.0), and in the clarithromycin group, the median age was 9.0 years (IQR: 7.0-13.0) (p = 0.793). The median time to clinical resolution was 3.0 days (IQR: 2.0-3.0) in the azithromycin group and 2.0 days (IQR: 2.0-3.0) in the clarithromycin group (p = 0.132). There were no significant differences in the duration of individual symptoms, including fever, vomiting, and abdominal pain. The length of hospital stay was also similar, with a median stay of 4 days (IQR: 3.0-5.0) in both groups (p = 0.394). Both antibiotics were well-tolerated, with no significant adverse events or treatment discontinuation reported.

Conclusions: Clarithromycin was found to be as effective as azithromycin in treating pediatric Campylobacter enterocolitis, with similar clinical outcomes and improvements in laboratory markers.

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口服阿奇霉素三天与口服克拉霉素五天治疗儿童弯曲杆菌肠炎的对比：一项前瞻性研究。

研究目的本研究旨在比较阿奇霉素和克拉霉素对小儿弯曲菌性小肠结肠炎的疗效和耐受性：方法：在一个中心进行了一项前瞻性随机对照试验。确诊为弯曲杆菌肠炎的患者被随机分配到接受为期 3 天的阿奇霉素疗程或为期 5 天的克拉霉素疗程。每天监测症状，比较实验室指标（白细胞计数、CRP水平和粪便钙蛋白）的变化：结果：共纳入29名儿童患者，其中阿奇霉素组14名，克拉霉素组15名。阿奇霉素组患者的中位年龄为 10.0 岁（四分位间距 [IQR]：5.0-13.0），克拉霉素组患者的中位年龄为 9.0 岁（四分位间距 [IQR]：7.0-13.0）（P = 0.793）。阿奇霉素组临床症状缓解的中位时间为 3.0 天（IQR：2.0-3.0），克拉霉素组为 2.0 天（IQR：2.0-3.0）（p = 0.132）。发热、呕吐和腹痛等个别症状的持续时间没有明显差异。两组患者的住院时间也相似，中位住院时间均为 4 天（IQR：3.0-5.0）（p = 0.394）。两种抗生素的耐受性都很好，没有明显的不良反应或中断治疗的报告：结论：克拉霉素与阿奇霉素治疗小儿弯曲菌性肠炎的疗效相同，临床结果和实验室指标改善情况相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

7.30

自引率

14.60%

发文量

1547

审稿时长

11 weeks

期刊介绍： Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.