Depression, anxiety and cognitive function in persons with inflammatory rheumatic diseases: cross-sectional results from the German National Cohort (NAKO).

IF 5.1 2区 医学 Q1 RHEUMATOLOGY
Johanna Callhoff, Klaus Berger, Katinka Albrecht, Anja Strangfeld
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引用次数: 0

Abstract

Objective: To assess the presence of mental health disorders in persons with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), systemic lupus erythematosus (SLE) and Sjögren's disease (SjD) (all: inflammatory rheumatic disease, iRMD) in a population-based cohort.

Methods: Baseline data from 101 601 participants of the German National Cohort (NAKO) were analysed. Self-reported physician's diagnoses of depression and anxiety, the depression scale of the Patient Health Questionnaire (PHQ-9), the Generalised Anxiety Disorder Symptoms Scale (GAD-7), the depression section of the Mini-International Neuropsychiatric Interview (MINI) and cognitive tests on memory and executive functions were analysed. Results of participants with iRMD were compared with participants with osteoarthritis (OA), stratified by age and sex. Cognitive function was described for iRMD and OA using a linear regression model, adjusted for sex and education.

Results: n=3257 participants (3.2%) had an iRMD (2.3% RA, 0.6% AS, 0.5% PsA, 0.2% SLE, 0.1% SjD) and n=24 030 (24%) had OA. Physicians' diagnoses of depression (26% vs 21%), anxiety (15% vs 11%), current depressive (PHQ-9 ≥10: 13% vs 9.0%) and anxiety symptoms (GAD-7 ≥10: 8.6% vs 5.8%) were more frequent in iRMDs compared with OA. In all age groups, women were more often affected than men. Linear regression models showed no differences in neuropsychological test results between iRMD and OA.

Conclusion: Individuals with iRMD frequently experience mental disorders. The study provides an assessment of both self-report and test-based occurrences in this group. Depression and anxiety are more frequent in iRMD compared with OA, whereas levels of cognitive dysfunction were comparable.

炎症性风湿病患者的抑郁、焦虑和认知功能:德国国家队列(NAKO)的横断面结果。
目的在基于人群的队列中评估类风湿性关节炎(RA)、强直性脊柱炎(AS)、银屑病关节炎(PsA)、系统性红斑狼疮(SLE)和斯约格伦病(SjD)(均为炎症性风湿病,iRMD)患者是否存在心理健康障碍:方法:分析了德国国家队列(NAKO)101 601 名参与者的基线数据。方法:分析了德国国家队列(NAKO)中 101 601 名参与者的基线数据,包括抑郁症和焦虑症的自我报告医生诊断、患者健康问卷(PHQ-9)中的抑郁量表、广泛性焦虑症症状量表(GAD-7)、迷你国际神经精神病学访谈(MINI)中的抑郁部分以及记忆和执行功能认知测试。将患有 iRMD 的参与者的结果与患有骨关节炎 (OA) 的参与者的结果进行了比较,并按年龄和性别进行了分层。结果:3257 名参与者(3.2%)患有 iRMD(2.3% RA、0.6% AS、0.5% PsA、0.2% SLE、0.1% SjD),24 030 名参与者(24%)患有 OA。与 OA 相比,iRMD 患者更常被医生诊断为抑郁(26% vs 21%)、焦虑(15% vs 11%)、当前抑郁(PHQ-9 ≥10:13% vs 9.0%)和焦虑症状(GAD-7 ≥10:8.6% vs 5.8%)。在所有年龄组中,女性患者多于男性。线性回归模型显示,iRMD 和 OA 的神经心理测试结果没有差异:结论:iRMD 患者经常会出现精神障碍。本研究对这一群体的自我报告和测试结果进行了评估。与 OA 相比,抑郁和焦虑在 iRMD 患者中更为常见,而认知功能障碍的程度则相当。
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来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
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