Transcutaneous auricular vagus nerve stimulation for long-term post-stroke cognitive impairment: a DTI case report.

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Frontiers in Human Neuroscience Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI:10.3389/fnhum.2024.1473535
Xixi Chen, Zhiqing Zhou, Kayee Chong, Jingjun Zhao, Yuwei Wu, Meng Ren, Yu Huang, Songmei Chen, Chunlei Shan
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引用次数: 0

Abstract

Purpose: Long-term post-stroke cognitive impairment (PSCI) exhibits an accelerated rate of long-term cognitive decline, which can impair communication, limit social engagement, and increase rate of institutional dependence. The aim of this case report is to provide evidence for the potential of home-based transcutaneous auricular vagus nerve stimulation (taVNS) for home-bound patients with severe, long-term PSCI.

Methods: A 71-year-old male suffered a stroke two and a half years ago, which imaging reported foci of cerebral infarction visible in the left temporal and parietal lobes. The patient was performed taVNS twice a day for 30 min, 5 times a week for 8 weeks. The patient was evaluated the changes of cognitive function and brain white matter at 4 time points: baseline (t0), 4 weeks without taVNS after baseline (t1), 4 weeks of intervention (t2), and 8 weeks of intervention (t3). The effect of taVNS on white matter changes was visualized by DTI.

Results: After 8 weeks of taVNS treatment, the scores of Montreal cognitive assessment improved and the time to complete the shape trails test decreased. The DTI results showed that white matter in bilateral dorsal lateral prefrontal cortex remodeled after taVNS.

Conclusion: Eight-week home-based taVNS may be beneficial to long-term PSCI. Further studies of home-based taVNS treating patients with long-term PSCI are needed.

经皮耳迷走神经刺激治疗中风后长期认知障碍:DTI 病例报告。
目的:脑卒中后长期认知障碍(PSCI)会加速长期认知功能的衰退,从而影响交流、限制社会参与并增加对机构的依赖性。本病例报告旨在提供证据,证明经皮耳廓迷走神经刺激术(taVNS)对长期卧床的重度认知障碍患者具有治疗潜力:一名 71 岁的男性患者两年半前中风,造影显示左侧颞叶和顶叶可见脑梗塞灶。患者接受了 taVNS 治疗,每天两次,每次 30 分钟,每周 5 次,共 8 周。在 4 个时间点评估了患者认知功能和脑白质的变化:基线(t0)、基线后 4 周未进行 taVNS(t1)、干预 4 周(t2)和干预 8 周(t3)。通过 DTI 观察 taVNS 对白质变化的影响:结果:经过 8 周的 taVNS 治疗后,蒙特利尔认知评估的得分有所提高,完成形状轨迹测试的时间缩短。DTI 结果显示,双侧背外侧前额叶皮质的白质在 taVNS 治疗后发生了重塑:结论:为期八周的居家 taVNS 可能对长期的 PSCI 有益。需要进一步研究基于家庭的 taVNS 治疗长期 PSCI 患者的效果。
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来源期刊
Frontiers in Human Neuroscience
Frontiers in Human Neuroscience 医学-神经科学
CiteScore
4.70
自引率
6.90%
发文量
830
审稿时长
2-4 weeks
期刊介绍: Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
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