Redox Signaling in Endosomes Using the Example of EGF Receptors: A Graphical Review.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Dana Maureen Hebchen, Katrin Schröder
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引用次数: 0

Abstract

Early endosomes represent first-line sorting compartments or even organelles for internalized molecules. They enable the transport of molecules or ligands to other compartments of the cell, such as lysosomes, for degradation or recycle them back to the membrane by various mechanisms. Moreover, early endosomes function as signaling and scaffolding platforms to initiate or prolong distinct signaling pathways. Accordingly, early endosomes have to be recognized as either part of a degradation or recycling pathway. The physical proximity of many ligand-binding receptors with other membrane-bound proteins or complexes such as NADPH oxidases may result in an interaction of second messengers, like reactive oxygen species (ROS) and early endosomes, that promote the correct recognition of individual early endosomes. In fact, redoxosomes comprise an endosomal subsection of signaling endosomes. One example of such potential interaction is epidermal growth factor receptor (EGFR) signaling. Here we summarize recent findings on EGFR signaling as a well-studied example for receptor trafficking and trans-activation and illustrate the interplay between cellular and endosomal ROS.

以表皮生长因子受体为例分析内体中的氧化还原信号:图解回顾。
早期内体是内化分子的一线分拣区室甚至细胞器。它们能将分子或配体运送到细胞的其他区室(如溶酶体)进行降解,或通过各种机制将其回收到膜上。此外,早期内体还发挥着信号和支架平台的作用,启动或延长不同的信号通路。因此,早期内体必须被识别为降解或回收途径的一部分。许多配体结合受体与其他膜结合蛋白或复合物(如 NADPH 氧化酶)的物理相近性可能会导致活性氧(ROS)等第二信使与早期内体的相互作用,从而促进对单个早期内体的正确识别。事实上,氧化还原酶体是信号内体的一个内体分部。表皮生长因子受体(EGFR)信号传导就是这种潜在相互作用的一个例子。在此,我们总结了表皮生长因子受体信号转导的最新研究成果,将其作为受体转运和反式激活的一个研究范例,并说明细胞和内体 ROS 之间的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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