One-Year Impact of Occupational Exposure to Polycyclic Aromatic Hydrocarbons on Sperm Quality.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-09-29 DOI:10.3390/antiox13101181

Mª Victoria Peña-García, Mª José Moyano-Gallego, Sara Gómez-Melero, Rafael Molero-Payán, Fernando Rodríguez-Cantalejo, Javier Caballero-Villarraso

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引用次数: 0

Abstract

Background: Polycyclic aromatic hydrocarbons (PAHs) have toxic potential, especially as carcinogens, neurotoxins, and endocrine disruptors. The objective of this study is to know the impact of exposure to PAHs on the reproductive health of male workers who operate in solar thermal plants.

Methods: Case-control study. A total of 61 men were included: 32 workers exposed to PAH at a solar thermal plant and 29 unexposed people. Seminal quality was studied both at the cellular level (quantity and quality of sperm) and at the biochemical level (magnitudes of oxidative stress in seminal plasma).

Results: In exposure to PAHs, a significantly higher seminal leukocyte infiltration was observed, as well as lower activity in seminal plasma of superoxide dismutase (SOD) and a reduced glutathione/oxidised glutathione (GSH/GSSG) ratio. The oxidative stress parameters of seminal plasma did not show a relationship with sperm cellularity, neither in those exposed nor in those not exposed to PAH.

Conclusion: One year of exposure to PAH in a solar thermal plant does not have a negative impact on the sperm cellularity of the worker, either quantitatively (sperm count) or qualitatively (motility, vitality, morphology, or cellular DNA fragmentation). However, PAH exposure is associated with lower antioxidant capacity and higher leukocyte infiltration in seminal plasma.

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职业暴露于多环芳烃对精子质量的一年影响

背景：多环芳烃（PAHs）具有潜在毒性，尤其是作为致癌物、神经毒素和内分泌干扰物。本研究的目的是了解接触多环芳烃对光热厂男工生殖健康的影响：方法：病例对照研究。方法：病例对照研究：方法：病例对照研究共纳入 61 名男性：32 名接触多环芳烃的太阳能热电厂工人和 29 名未接触者。从细胞水平（精子的数量和质量）和生化水平（精浆中氧化应激的大小）对精液质量进行了研究：结果：在暴露于多环芳烃的情况下，观察到精液中的白细胞浸润明显增加，精浆中超氧化物歧化酶（SOD）的活性和还原型谷胱甘肽/氧化型谷胱甘肽（GSH/GSSG）的比率降低。无论是暴露于多环芳烃还是未暴露于多环芳烃的人群，精浆中的氧化应激参数均未显示出与精子细胞性的关系：结论：在太阳能热电厂工作一年并接触多环芳烃不会对工人的精子细胞数量（精子数量）或质量（活力、生命力、形态或细胞 DNA 片段）产生负面影响。然而，接触多环芳烃会导致抗氧化能力降低和精浆中白细胞浸润增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.