Nitric Oxide Signaling and Sensing in Age-Related Diseases.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-10-09 DOI:10.3390/antiox13101213

Olga Mazuryk, Ilona Gurgul, Maria Oszajca, Justyna Polaczek, Konrad Kieca, Ewelina Bieszczad-Żak, Tobiasz Martyka, Grażyna Stochel

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引用次数: 0

Abstract

Nitric oxide (NO) is a key signaling molecule involved in numerous physiological and pathological processes within the human body. This review specifically examines the involvement of NO in age-related diseases, focusing on the cardiovascular, nervous, and immune systems. The discussion delves into the mechanisms of NO signaling in these diseases, emphasizing the post-translational modifications of involved proteins, such as S-nitrosation and nitration. The review also covers the dual nature of NO, highlighting both its protective and harmful effects, determined by concentration, location, and timing. Additionally, potential therapies that modulate NO signaling, including the use of NO donors and nitric oxide synthases (NOSs) inhibitors in the treatment of cardiovascular, neurodegenerative, and oncological diseases, are analyzed. Particular attention is paid to the methods for the determination of NO and its derivatives in the context of illness diagnosis and monitoring. The review underscores the complexity and dual role of NO in maintaining cellular balance and suggests areas for future research in developing new therapeutic strategies.

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一氧化氮在老年相关疾病中的信号传导和感应。

一氧化氮（NO）是一种关键的信号分子，参与了人体的许多生理和病理过程。这篇综述特别探讨了一氧化氮与年龄相关疾病的关系，重点是心血管、神经和免疫系统。讨论深入探讨了 NO 信号在这些疾病中的作用机制，强调了相关蛋白质的翻译后修饰，如 S-亚硝基化和硝化。综述还涵盖了氮氧化物的双重性质，强调了氮氧化物的保护作用和有害作用，这取决于浓度、位置和时间。此外，还分析了调节 NO 信号转导的潜在疗法，包括使用 NO 供体和一氧化氮合酶（NOS）抑制剂治疗心血管、神经退行性疾病和肿瘤疾病。特别关注了在疾病诊断和监测中测定一氧化氮及其衍生物的方法。综述强调了 NO 在维持细胞平衡方面的复杂性和双重作用，并提出了未来开发新治疗策略的研究领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.