Melatonin's Impact on Wound Healing.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-10-02 DOI:10.3390/antiox13101197

Eun-Hwa Sohn, Su-Nam Kim, Sung-Ryul Lee

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Abstract

Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various tissues, such as the skin and intestines. Melatonin's effects in target tissues can be mediated through receptor-dependent mechanisms. Additionally, melatonin exerts various actions via receptor-independent pathways. In biological systems, melatonin and its endogenous metabolites often produce similar effects. While injuries are common in daily life, promoting optimal wound healing is essential for patient well-being and healthcare outcomes. Beyond regulating circadian rhythms as a neuroendocrine hormone, melatonin may enhance wound healing through (1) potent antioxidant properties, (2) anti-inflammatory actions, (3) infection control, (4) regulation of vascular reactivity and angiogenesis, (5) analgesic (pain-relieving) effects, and (6) anti-pruritic (anti-itch) effects. This review aims to provide a comprehensive overview of scientific studies that demonstrate melatonin's potential roles in supporting effective wound healing.

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褪黑激素对伤口愈合的影响

褪黑素（5-甲氧基-N-乙酰色胺）是一种吲哚胺化合物，在调节昼夜节律方面起着至关重要的作用。褪黑素主要由大脑松果体中的色氨酸氨基酸合成，也可在皮肤和肠道等多种组织中产生。褪黑素在目标组织中的作用可通过受体依赖机制介导。此外，褪黑激素还可通过与受体无关的途径发挥各种作用。在生物系统中，褪黑激素及其内源性代谢物通常会产生类似的作用。受伤在日常生活中很常见，促进伤口的最佳愈合对患者的健康和医疗效果至关重要。除了作为一种神经内分泌激素调节昼夜节律外，褪黑激素还可通过以下作用促进伤口愈合：（1）强效抗氧化特性；（2）抗炎作用；（3）感染控制；（4）调节血管反应性和血管生成；（5）镇痛作用；（6）止痒作用。本综述旨在全面概述证明褪黑激素在支持有效伤口愈合方面潜在作用的科学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.