Vidya P Kumar, Yali Kong, Riana Dolland, Sandra R Brown, Kan Wang, Damian Dolland, David Mu, Milton L Brown
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引用次数: 0
Abstract
Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effective therapeutic strategies require a deep understanding of the mechanisms underlying RIC formation (RICF). This study investigates the roles of angiotensin II (Ang II) and oxidative stress in RIC development, with a focus on their combined effects on lens transparency and cellular function. Key mechanisms include the generation of reactive oxygen species (ROS) and oxidative damage to lens proteins and lipids, as well as the impact of Ang II on inflammatory responses and cellular apoptosis. While the generation of ROS from water radiolysis is well established, the impact of Ang II on RICs is less understood. Ang II intensifies oxidative stress by activating type 1 receptors (AT1Rs) on lens epithelial cells, resulting in increased ROS production and inflammatory responses. This oxidative damage leads to protein aggregation, lipid peroxidation, and apoptosis, ultimately compromising lens transparency and contributing to cataract formation. Recent studies highlight Ang II's dual role in promoting both oxidative stress and inflammation, which accelerates cataract development. RICs pose a substantial public health concern due to their widespread prevalence and impact on quality of life. Targeting Ang II signaling and oxidative stress simultaneously could represent a promising therapeutic approach. Continued research is necessary to validate these strategies and explore their efficacy in preventing or reversing RIC development.
辐射诱发的白内障(RICs)是一项重大的公共卫生挑战,尤其影响到因医疗、职业环境和环境因素而暴露于电离辐射(IR)的人。有效的治疗策略需要深入了解 RIC(RICF)的形成机制。本研究探讨了血管紧张素 II(Ang II)和氧化应激在 RIC 形成过程中的作用,重点是它们对晶状体透明度和细胞功能的综合影响。关键机制包括活性氧(ROS)的生成、晶状体蛋白质和脂质的氧化损伤以及血管紧张素 II 对炎症反应和细胞凋亡的影响。水的辐射分解产生的 ROS 已得到公认,但 Ang II 对 RIC 的影响却鲜为人知。Ang II 通过激活晶状体上皮细胞上的 1 型受体(AT1Rs)来加强氧化应激,导致 ROS 生成增加和炎症反应。这种氧化损伤会导致蛋白质聚集、脂质过氧化和细胞凋亡,最终损害晶状体的透明度并导致白内障的形成。最近的研究强调了血管紧张素 II 在促进氧化应激和炎症方面的双重作用,这加速了白内障的发展。由于 RIC 的广泛流行和对生活质量的影响,RIC 构成了一个重大的公共卫生问题。同时靶向 Ang II 信号传导和氧化应激可能是一种很有前景的治疗方法。有必要继续开展研究,以验证这些策略并探索其在预防或逆转 RIC 发展方面的疗效。
AntioxidantsBiochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍:
Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.