New Discorhabdin D Analogues from Latrunculia spp. Sponges.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2024-11-22 Epub Date: 2024-10-25 DOI:10.1021/acs.jnatprod.4c01036

Maria Orfanoudaki, Masoumeh Dalilian, Lin Du, Cindy H Chau, William D Figg, Barry R O'Keefe, Tanja Grkovic

引用次数: 0

Abstract

Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.

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从 Latrunculia spp.海绵中提取的新 Discorhabdin D 类似物。

通过对 Latrunculia kaakaariki 和 Latrunculia brevis 的化学特征进行研究，分离出了五种新的 Discorhabdin D 衍生物 1 和 3-6。结合核磁共振和 HR-MS 解决了它们的平面结构，同时使用基于 J 的构型分析、计算技术和半合成方法确定了它们的绝对构型。测试了新天然产物对 NCI-60 人类肿瘤细胞系的生长抑制活性，其中两个化合物 5 和 6 显示出较低的微摩尔效力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.