A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age.

IF 17 Q1 CELL BIOLOGY
Jorge Martinez-Romero, Maria Emilia Fernandez, Michel Bernier, Nathan L Price, William Mueller, Julián Candia, Simonetta Camandola, Osorio Meirelles, Yi-Han Hu, Zhiguang Li, Nigus Asefa, Andrew Deighan, Camila Vieira Ligo Teixeira, Dushani L Palliyaguru, Carlos Serrano, Nicolas Escobar-Velasquez, Stephanie Dickinson, Eric J Shiroma, Luigi Ferrucci, Gary A Churchill, David B Allison, Lenore J Launer, Rafael de Cabo
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Abstract

Biological clocks and other molecular biomarkers of aging are difficult to implement widely in a clinical setting. In this study, we used routinely collected hematological markers to develop an aging clock to predict blood age and determine whether the difference between predicted age and chronologic age (aging gap) is associated with advanced aging in mice. Data from 2,562 mice of both sexes and three strains were drawn from two longitudinal studies of aging. Eight hematological variables and two metabolic indices were collected longitudinally (12,010 observations). Blood age was predicted using a deep neural network. Blood age was significantly correlated with chronological age, and aging gap was positively associated with mortality risk and frailty. Platelets were identified as the strongest age predictor by the deep neural network. An aging clock based on routinely collected blood measures has the potential to provide a practical clinical tool to better understand individual variability in the aging process.

根据小鼠纵向衰老研究得出的血液学时钟来估算生物年龄。
生物钟和其他衰老分子生物标志物很难在临床环境中广泛应用。在这项研究中,我们利用日常收集的血液标记物开发了一种衰老时钟来预测血液年龄,并确定预测年龄与实际年龄之间的差异(衰老差距)是否与小鼠的晚期衰老有关。我们从两项衰老纵向研究中收集了 2,562 只小鼠的数据,其中包括三种品系的雌雄小鼠。研究人员纵向收集了八个血液学变量和两个代谢指数(12010 个观测值)。使用深度神经网络预测了血液年龄。血液年龄与计时年龄有明显的相关性,而衰老差距与死亡风险和虚弱程度呈正相关。血小板被深度神经网络确定为预测年龄的最强指标。基于日常收集的血液指标的老化时钟有可能提供一种实用的临床工具,以更好地了解衰老过程中的个体差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.70
自引率
0.00%
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