Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-10-17 DOI:10.1016/j.arr.2024.102552

Olga Chervova , Kseniia Panteleeva , Elizabeth Chernysheva , Tyas Arum Widayati , Žan Florjanic Baronik , Natálie Hrbková , Jadesada Louis Schneider , Martin Bobak , Stephan Beck , Vitaly Voloshin

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引用次数: 0

Abstract

Epigenetic clocks provide an accurate molecular readout of epigenetic age and epigenetic age acceleration (EAA) derived from DNA methylation data have shown promise as biomarkers of ageing. This systematic review synthesised research on associations between EAA measures and various physiological, cognitive, social, and environmental factors. A comprehensive search strategy identified 299 publications reporting 1050 unique EAA-factor associations based on 53 methylation clocks. Random-effects meta-analyses pooled results across studies for selected EAA-factor pairs. Significant pooled associations emerged, providing insights into relationships between specific factors and accelerated epigenetic ageing. We developed a novel four-level classification system to categorise this diverse range of factors and enable a structured synthesis. To aid further research planning in this rapidly evolving field, TEAPEE (Tracker of EAA Associations with Phenotype & Environmental Exposure) - an interactive, searchable web table detailing all EAA-factor associations - was developed, cataloguing the epigenetic clocks, associated factors, classification categories, and direct links to the original studies. This resource will empower future investigations into the multifaceted determinants of epigenetic ageing, contributing to a deeper understanding of the epigenome’s sensitivity to various life experiences and exposures.

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利用表观遗传时钟为人类健康和福祉开辟新天地：表观遗传年龄加速相关性的系统回顾和荟萃分析。

表观遗传时钟提供了表观遗传年龄的精确分子读数，而从 DNA 甲基化数据中得出的表观遗传年龄加速度（EAA）有望成为老化的生物标志物。本系统综述综合了有关 EAA 测量与各种生理、认知、社会和环境因素之间关系的研究。通过综合搜索策略发现了 299 篇出版物，这些出版物基于 53 个甲基化时钟报告了 1,050 个独特的 EAA 因素关联。随机效应荟萃分析对选定的 EAA 因素对的研究结果进行了汇总。研究发现了一些重要的集合关联，为了解特定因素与表观遗传加速衰老之间的关系提供了线索。我们开发了一种新颖的四级分类系统来对这些不同的因素进行分类，并进行结构化综合。为了帮助这一快速发展领域的进一步研究规划，我们开发了 TEAPEE（表型与环境暴露的表观遗传加速老化关联追踪器）--一个详细列出所有表观遗传加速老化关联因素的可搜索互动式网络表格，对表观遗传时钟、关联因素、分类类别和原始研究的直接链接进行了编目。这一资源将有助于今后对表观遗传老化的多方面决定因素进行研究，有助于加深对表观基因组对各种生活经历和暴露的敏感性的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.