Association of novel dietary and lifestyle inflammation scores with incidence and progression of coronary artery calcification in middle-late adulthood: a longitudinal cohort study.

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS
Azra Ramezankhani, Parto Hadaegh, Farzad Hadaegh
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引用次数: 0

Abstract

Background: Dietary patterns and lifestyle factors can influence the intensity of systemic inflammation and, consequently, the development and progression of coronary artery calcification (CAC). This study aimed to explore the relationship between the inflammatory potentials of diet and lifestyle, as captured by novel dietary and lifestyle inflammation scores (DIS and LIS), with CAC incidence and progression.

Methods: We analyzed data on 5949 Black and White men and women ≥ 45 years old participating in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Baseline data on diet and lifestyle factors were collected from 2000 to 2002 and used to construct the DIS and LIS, which reflect the overall inflammatory potential of diet and lifestyle. Cox proportional hazard regression was used to calculate the hazard ratios (HR) and 95% confidence intervals (95% CI) for CAC incidence and progression across quartiles of DIS and LIS, adjusting for potential confounders.

Results: Over a median follow-up of 8.0 years, among 2638 participants with zero CAC score at baseline, 977 individuals developed positive scores, and 1681 out of 2561 participants showed CAC progression. For individuals in the highest (more pro-inflammatory) compared to the lowest (more anti-inflammatory) quartiles of the LIS, the multivariable-adjusted HR for CAC incidence was 1.35 (95% CI, 1.10-1.65; P trend < 0.002). This association was stronger among younger adults aged < 60 years compared to those aged ≥ 60 years, with respective values of 1.76 (1.34-2.30) and 1.02 (0.78-1.35) (P interaction < 0.001). However, the LIS was not significantly associated with the progression of existing CAC. Among the components of the LIS, a body mas index (BMI) ≥ 25 kg/m2 and current smoking were significant predictors for the incidence and progression of CAC, respectively. No significant association was found between DIS and CAC incidence and progression.

Conclusions: Lifestyle factors, through their impact on systemic inflammation, may be associated with a higher risk of CAC incidence in middle and late adulthood.

新型饮食和生活方式炎症评分与中晚年冠状动脉钙化的发生和发展的关系:一项纵向队列研究。
背景:饮食模式和生活方式因素会影响全身炎症的强度,进而影响冠状动脉钙化(CAC)的发生和发展。本研究旨在探讨新型饮食和生活方式炎症评分(DIS 和 LIS)所反映的饮食和生活方式的炎症潜能与 CAC 发病率和进展之间的关系:我们分析了参加动脉粥样硬化多种族研究(MESA)队列的 5949 名年龄≥ 45 岁的黑人和白人男女的数据。研究人员从 2000 年到 2002 年收集了有关饮食和生活方式因素的基线数据,并利用这些数据构建了 DIS 和 LIS,它们反映了饮食和生活方式的整体炎症潜能。在调整潜在的混杂因素后,采用 Cox 比例危险回归法计算 DIS 和 LIS 四分位数中 CAC 发病率和进展的危险比 (HR) 和 95% 置信区间 (95%CI):在中位随访 8.0 年期间,在 2638 名基线 CAC 分数为零的参与者中,有 977 人出现了阳性分数,2561 名参与者中有 1681 人出现了 CAC 进展。与 LIS 四分位数最低(抗炎性较强)的人相比,LIS 四分位数最高(抗炎性较强)的人经多变量调整后的 CAC 发生率为 1.35(95% CI,1.10-1.65;P 趋势 2 和当前吸烟分别是 CAC 发生率和进展的重要预测因素。DIS与CAC发病率和进展之间没有明显关联:结论:生活方式因素对全身炎症的影响可能与中晚年CAC发病风险较高有关。
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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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