Association between fish oil and glucosamine use and mortality in patients diagnosed with cancer: the role of the Life Essential 8 score and cancer prognosis.

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS
Chun Sing Lam, Rong Hua, Herbert Ho-Fung Loong, Vincent Chi-Ho Chung, Yin Ting Cheung
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引用次数: 0

Abstract

Background: The effect of supplements on mortality risk in patients with cancer remains uncertain and has scarcely been investigated in subgroups of patients with varying characteristics. This study aimed to investigate the association between two popular supplements, fish oil and glucosamine, and mortality risk in a large population-based cohort and determine whether cardiovascular health and clinical prognosis influence these associations.

Methods: This prospective cohort study analyzed the data of UK Biobank participants who were diagnosed with cancer. The associations of fish oil and glucosamine consumption with mortality were analyzed using Cox proportional hazards models. Subgroup analyses were performed to assess the effects of Life Essential 8 [LE8] scores (a measure of cardiovascular health) and cancer prognosis (grouped according to the survival rates of specific cancer types) on the associations between supplement use and mortality.

Results: This analysis included 14,920 participants (mean age = 59.9 years; 60.2% female). One third (34.1%) of the participants reported using fish oil, and one fifth (20.5%) reported using glucosamine. Over a median follow-up of 12.0 years, 2,708 all-cause deaths were registered. The use of fish oil was associated with reduced risks of all-cause mortality (adjusted hazard ratio [aHR] = 0.89, 95% Confidence Interval [CI] = 0.81-0.97) and cancer mortality (aHR = 0.89, 95% CI = 0.81-0.98). Similarly, glucosamine use was associated with reduced risks of all-cause mortality (aHR = 0.83, 95% CI = 0.74-0.92) and cancer mortality (aHR = 0.83, 95% CI = 0.74-0.93) in the fully adjusted model. Subgroup analyses revealed that the protective effects of fish oil and glucosamine against mortality risk were only observed in patients with LE8 scores lower than the mean score or a poor cancer prognosis. Additionally, the association between glucosamine use and a reduced risk of CVD-related mortality was only observed in patients with lower LE8 scores.

Conclusions: This large cohort study identified the potential differential impact of LE8 scores and cancer prognosis on the associations of fish oil and glucosamine supplementation with survival in patients with cancer. This suggests the importance of considering these factors in future research on supplements and in the provision of personalized integrative cancer care.

鱼油和氨基葡萄糖的使用与确诊癌症患者死亡率之间的关系:生命必备 8 评分和癌症预后的作用。
背景:保健品对癌症患者死亡风险的影响仍不确定,而且很少对具有不同特征的亚组患者进行调查。本研究旨在调查鱼油和氨基葡萄糖这两种流行的营养补充剂与大型人群队列中死亡风险之间的关联,并确定心血管健康和临床预后是否会影响这些关联:这项前瞻性队列研究分析了英国生物库中被诊断为癌症的参与者的数据。采用 Cox 比例危险模型分析了鱼油和氨基葡萄糖摄入量与死亡率的关系。还进行了分组分析,以评估生命必需8[LE8]评分(衡量心血管健康状况的指标)和癌症预后(根据特定癌症类型的存活率分组)对补充剂使用与死亡率之间关系的影响:这项分析包括 14 920 名参与者(平均年龄 = 59.9 岁;60.2% 为女性)。三分之一(34.1%)的参与者报告使用鱼油,五分之一(20.5%)的参与者报告使用氨基葡萄糖。在 12.0 年的中位随访期间,共登记了 2 708 例全因死亡。使用鱼油可降低全因死亡风险(调整后危险比 [aHR] = 0.89,95% 置信区间 [CI] = 0.81-0.97)和癌症死亡风险(aHR = 0.89,95% CI = 0.81-0.98)。同样,在完全调整模型中,服用氨基葡萄糖与全因死亡风险降低(aHR = 0.83,95% CI = 0.74-0.92)和癌症死亡风险降低(aHR = 0.83,95% CI = 0.74-0.93)相关。亚组分析显示,鱼油和氨基葡萄糖对死亡风险的保护作用仅在LE8评分低于平均分或癌症预后较差的患者中观察到。此外,只有在LE8评分较低的患者中才能观察到使用氨基葡萄糖与降低心血管疾病相关死亡风险之间的联系:这项大型队列研究发现了LE8评分和癌症预后对补充鱼油和氨基葡萄糖与癌症患者生存率之间关系的潜在不同影响。这表明,在未来的营养补充剂研究和提供个性化综合癌症治疗时,考虑这些因素非常重要。
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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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