Association of Ambient Air Pollution Exposure With Incident Glaucoma: 12-Year Evidence From the UK Biobank Cohort.

IF 5 2区 医学 Q1 OPHTHALMOLOGY
Zihan Sun, Kelsey V Stuart, Robert N Luben, Amy L Auld, Nicholas G Strouthidis, Peng T Khaw, Hari Jayaram, Anthony P Khawaja, Paul J Foster
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Abstract

Purpose: Glaucoma is the leading cause of irreversible blindness worldwide. Despite growing concerns about air quality and its impact on ocular health, there remains a knowledge gap regarding the long-term association between air pollution and glaucoma risk. This study investigates the relationship between exposure to ambient air pollution and incidence of glaucoma.

Methods: In this prospective study, we used land use regression models to estimate levels of various air pollutants, including fine particulate matter (PM2.5), PM2.5 absorbance, PM2.5-10, PM10, nitrogen dioxide (NO2), and nitrogen oxides (NOx). Incidents of glaucoma were ascertained through routinely collected hospital admission records. Multivariate Cox proportional hazards models were used to examine the associations between air pollution exposure and glaucoma incidence, adjusting for potential confounding sociodemographic, physical, and lifestyle factors.

Results: Data from 481,113 participants were included. Over a median follow-up of 12.8 years, 9224 incident cases of glaucoma were identified. In the maximally adjusted model, per interquartile range increase in PM2.5 was associated with a 3% greater risk of developing glaucoma (hazard ratio [HR] = 1.03, 95% confidence interval [CI] = 1.00 to 1.06, P = 0.048). Participants in the highest quartile had a 10% increased risk of developing glaucoma compared to those in the lowest quartile (HR = 1.10, 95% CI = 1.03 to 1.17, P = 0.005).

Conclusions: Higher levels of exposure to ambient air pollutants, particularly PM2.5, are associated with an increased risk of developing glaucoma. These results highlight the potential public health impact of ambient air pollution on glaucoma risk and underscore the urgent need for further research into targeted environmental interventions in this domain.

环境空气污染暴露与青光眼发病率的关系:英国生物库队列 12 年的证据。
目的:青光眼是导致全球不可逆失明的主要原因。尽管人们越来越关注空气质量及其对眼部健康的影响,但在空气污染与青光眼风险之间的长期关系方面仍存在知识空白。本研究调查了暴露于环境空气污染与青光眼发病率之间的关系:在这项前瞻性研究中,我们使用土地利用回归模型来估算各种空气污染物的水平,包括细颗粒物(PM2.5)、PM2.5 吸收率、PM2.5-10、PM10、二氧化氮(NO2)和氮氧化物(NOx)。青光眼病例通过常规收集的入院记录确定。采用多变量考克斯比例危险模型来研究空气污染暴露与青光眼发病率之间的关系,并对可能混杂的社会人口、身体和生活方式因素进行调整:研究纳入了 481 113 名参与者的数据。中位随访时间为 12.8 年,共发现 9224 例青光眼病例。在最大调整模型中,PM2.5每增加1个四分位数,患青光眼的风险就增加3%(危险比[HR] = 1.03,95%置信区间[CI] = 1.00至1.06,P = 0.048)。与最低四分位数的参与者相比,最高四分位数的参与者患青光眼的风险增加了 10%(HR = 1.10,95% CI = 1.03 至 1.17,P = 0.005):环境空气污染物,尤其是 PM2.5 暴露水平越高,患青光眼的风险就越高。这些结果突显了环境空气污染对青光眼风险的潜在公共健康影响,并强调了在这一领域进一步研究有针对性的环境干预措施的迫切需要。
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来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
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