Species diversity and network diversity in the human lung cancer tissue microbiomes.

IF 2.2 4区生物学 Q3 MICROBIOLOGY

Fems Microbiology Letters Pub Date : 2024-01-09 DOI:10.1093/femsle/fnae087

Yuting Qiao, Jiandong Mei, Zhanshan Sam Ma

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引用次数: 0

Abstract

This study explores the relationship between microbial diversity and disease status in human lung cancer tissue microbiomes, using a sample size of 1212. Analysis divided the data into primary tumour (PT) and normal tissue (NT) categories. Differences in microbial diversity between PT and NT were significant in 57% of comparisons, although dataset dependence was a factor in the diversity levels. Shared species analysis (SSA) indicated no significant differences between PT and NT in over 90% of comparisons. Network diversity assessments revealed significant differences between NT and PT regarding species relative abundances and network link abundances for q = 0-3. Additionally, significant variations were found between NT and lung squamous cell carcinoma (LUSC) at q = 0. in network link probabilities, illustrating the diversity in species interactions. Our findings suggest a stable overall microbiome diversity and composition in lung cancer patients' lung tissues despite patients with diagnosed lung tumours, indicating modified microbial interactions within the tumour. These results highlight an association between altered microbiome interaction patterns and lung tumours, offering new insights into the ecological dynamics of lung cancer microbiomes.

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人类肺癌组织微生物组的物种多样性和网络多样性

本研究利用 1,212 个样本探讨了人类肺癌组织微生物组中微生物多样性与疾病状态之间的关系。分析将数据分为原发性肿瘤（PT）和正常组织（NT）两类。在57%的比较中，PT和NT之间微生物多样性的差异显著，尽管数据集依赖性是影响多样性水平的一个因素。共有物种分析（SSA）表明，在超过 90% 的比较中，PT 和 NT 之间没有显著差异。网络多样性评估显示，在 q=0-3 条件下，NT 与 PT 在物种相对丰度和网络链接丰度方面存在显著差异。此外，在 q=0 时，NT 和 LUSC 在网络链接概率方面存在显著差异，这说明了物种相互作用的多样性。我们的研究结果表明，尽管肺癌患者已确诊为肺部肿瘤，但其肺部组织中微生物组的多样性和组成总体上是稳定的，这表明肿瘤内微生物的相互作用发生了改变。这些结果突显了微生物组相互作用模式的改变与肺部肿瘤之间的关联，为肺癌微生物组的生态动态提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fems Microbiology Letters 生物-微生物学

CiteScore

4.30

自引率

0.00%

发文量

112

审稿时长

1.9 months

期刊介绍： FEMS Microbiology Letters gives priority to concise papers that merit rapid publication by virtue of their originality, general interest and contribution to new developments in microbiology. All aspects of microbiology, including virology, are covered. 2019 Impact Factor: 1.987, Journal Citation Reports (Source Clarivate, 2020) Ranking: 98/135 (Microbiology) The journal is divided into eight Sections: Physiology and Biochemistry (including genetics, molecular biology and ‘omic’ studies) Food Microbiology (from food production and biotechnology to spoilage and food borne pathogens) Biotechnology and Synthetic Biology Pathogens and Pathogenicity (including medical, veterinary, plant and insect pathogens – particularly those relating to food security – with the exception of viruses) Environmental Microbiology (including ecophysiology, ecogenomics and meta-omic studies) Virology (viruses infecting any organism, including Bacteria and Archaea) Taxonomy and Systematics (for publication of novel taxa, taxonomic reclassifications and reviews of a taxonomic nature) Professional Development (including education, training, CPD, research assessment frameworks, research and publication metrics, best-practice, careers and history of microbiology) If you are unsure which Section is most appropriate for your manuscript, for example in the case of transdisciplinary studies, we recommend that you contact the Editor-In-Chief by email prior to submission. Our scope includes any type of microorganism - all members of the Bacteria and the Archaea and microbial members of the Eukarya (yeasts, filamentous fungi, microbial algae, protozoa, oomycetes, myxomycetes, etc.) as well as all viruses.