Exploring Saffron's Therapeutic Potential: Insights on Phytochemistry, Bioactivity, and Clinical Implications.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2024-10-16 DOI:10.2174/0113816128337941240928181943

Debasis Sen, Sunny Rathee, Vishal Pandey, Sanjay K Jain

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Abstract

Saffron, derived from the Crocus sativus plant, has been revered for centuries for its culinary, medicinal, and cultural significance. This review provides a comprehensive overview of saffron's chemical constituents and phytochemistry, elucidating its rich profile of bioactive compounds. Emphasis is placed on exploring the bio-accessibility, bioavailability, and bioactivity of saffron's phytochemicals, laying the foundation for understanding its pharmaceutical significance. The pharmaceutical importance of saffron and its phytochemicals is thoroughly examined, focusing on their diverse therapeutic properties. These include anticancer, antidiabetic, antioxidant, antimicrobial, anti-inflammatory, antinociceptive, anticonvulsant, antidepressant, learning and memory enhancement, cardiovascular, and antihypertensive properties. Such multifaceted pharmacological activities underscore saffron's potential as a valuable medicinal resource. Clinical studies investigating the efficacy and safety of saffron in various health conditions are synthesized, providing insights into its clinical applications. Moreover, toxicity assessments in animal models, encompassing acute, subacute, subchronic, and developmental toxicity, are discussed to delineate the safety profile of saffron and its bioactive constituents. Finally, recent advances and future perspectives in saffron research are highlighted, underscoring emerging trends and potential avenues for further exploration. This review serves as a comprehensive resource for researchers, clinicians, and stakeholders interested in harnessing the therapeutic potential of saffron while ensuring its safe and effective utilization in healthcare settings.

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探索藏红花的治疗潜力：关于植物化学、生物活性和临床意义的见解。

藏红花提取自 Crocus sativus 植物，几个世纪以来一直因其烹饪、药用和文化意义而备受推崇。本综述全面概述了藏红花的化学成分和植物化学，阐明了其丰富的生物活性化合物。重点探讨了藏红花植物化学成分的生物可及性、生物利用率和生物活性，为了解其制药意义奠定了基础。该书深入研究了藏红花及其植物化学物质的重要药用价值，重点关注它们的各种治疗特性。这些特性包括抗癌、抗糖尿病、抗氧化、抗菌、抗炎、抗过敏、抗惊厥、抗抑郁、增强学习和记忆能力、心血管和降压特性。这些多方面的药理作用凸显了藏红花作为宝贵药用资源的潜力。本研究综述了藏红花对各种健康状况的疗效和安全性的临床研究，为藏红花的临床应用提供了深入的见解。此外，还讨论了动物模型的毒性评估，包括急性、亚急性、亚慢性和发育毒性，以描述藏红花及其生物活性成分的安全性。最后，重点介绍了藏红花研究的最新进展和未来前景，强调了新出现的趋势和进一步探索的潜在途径。这篇综述为研究人员、临床医生和有兴趣利用藏红花治疗潜力的利益相关者提供了全面的资源，同时确保了藏红花在医疗保健环境中的安全和有效利用。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.