Dairy Foods: A Matrix for Human Health and Precision Nutrition—The relevance of a potential bioactive ingredient; The milk fat globule membrane

IF 3.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Journal of Dairy Science Pub Date : 2025-04-01 DOI:10.3168/jds.2024-25412

Leia Wilmot , Celeste Miller , Isha Patil , Alan L. Kelly , Rafael Jimenez-Flores

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Abstract

The milk fat globule membrane (MFGM) is a complex structure that surrounds the surface of fat globules in the milk of mammals. The MFGM is rich in bioactive compounds such as phospholipids, glycoproteins, and sphingolipids. Recent research highlights its important role in human health, particularly in infant nutrition, where it contributes to cognitive development, immune function, and gastrointestinal health. This review article examines the variability in commercial MFGM ingredients derived from dairy sources, detailing the impact of processes used to extrapolate the bioactive rich fractions from the MFGM. The potential applications of MFGM in food products, especially infant formulas, are emphasized, showcasing its ability to improve nutritional outcomes. Furthermore, the review discusses clinical studies that demonstrate the health benefits associated with MFGM supplementation, including enhanced cognitive performance and reduced incidence of infections in infants. Some of the underlying mechanisms behind the health-enhancing effects are elucidated in this review. Overall, this review underscores the importance of MFGM as a valuable bioactive ingredient in promoting health and development in early life nutrition.

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潜在生物活性成分的相关性：牛奶脂肪球膜

牛奶脂肪球膜（MFGM）是牛奶中三酰甘油致密脂肪球的周围膜。原生的乳脂球膜是在乳腺内乳细胞粗面内质网的脂质生物合成过程中形成的三层结构。它由三层磷脂、胆固醇、多种蛋白质、糖基化蛋白质和各种脂质组成（Brink 和 Lönnerdal，2020 年）。MFGM 的两个主要来源是黄油生产过程中产生的奶油和奶酪生产过程中产生的乳清。近年来，在营养产品（尤其是婴儿营养品）中使用 MFGM 成分受到了极大关注。如今，全球各地的不同供应商已经推出了一系列商业化的富含 MFGM 的配料。三层膜的基本成分磷脂和蛋白质已被证明在包括人体在内的各种模型中发挥生物活性作用。目前还不清楚这种复杂成分的组成差异如何影响乳制品基质中的 MFGM 的生物活性潜力。在加工过程中，乳脂网状结构会失去其原生的三层结构，形成乳脂网状结构碎片，从而变得更加复杂。本综述旨在阐明中链麦芽糖和麦芽糊精成分对人体健康产生生物活性效应的内在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dairy Science 农林科学-奶制品与动物科学

CiteScore

7.90

自引率

17.10%

发文量

784

审稿时长

4.2 months

期刊介绍： The official journal of the American Dairy Science Association®, Journal of Dairy Science® (JDS) is the leading peer-reviewed general dairy research journal in the world. JDS readers represent education, industry, and government agencies in more than 70 countries with interests in biochemistry, breeding, economics, engineering, environment, food science, genetics, microbiology, nutrition, pathology, physiology, processing, public health, quality assurance, and sanitation.