Nicotinamide Mononucleotide Improves Endometrial Homeostasis in a Rat Model of Polycystic Ovary Syndrome by Decreasing Insulin Resistance and Regulating the Glylytic Pathway

IF 4.5 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Wenhui Zhang, Jiaming Zhang, Haoxuan Xue, Xi Chen, Meixiang Li, Shenghua Chen, Zhiling Li, Leonardo Antonio Sechi, Qian Wang, Giampiero Capobianco, Xiaocan Lei
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Abstract

Scope

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that can lead to insulin resistance (IR) and dysregulation of glucose metabolism, resulting in an imbalance in the endometrial environment, which is unfavorable for embryo implantation of PCOS. This study aims to investigate whether nicotinamide mononucleotide (NMN) improves the stability of the endometrium in a rat model of PCOS and identifies whether it is related to reduce IR and increase glycolysis levels and its potential signaling pathway.

Methods and results

Female Sprague-Dawley (SD) rats are fed letrozole and a high-fat diet (HFD) to form the PCOS model, then the model rats are treated with or without NMN. It randomly divided into control, PCOS, and PCOS-NMN groups according to the feeding and treating method. Compared with the PCOS group, the regular estrous cycles are restored, the serum androgen (p<0.01) and fasting insulin levels (p<0.05) are reduced, and endometrial morphology (p<0.05) is improved in NMN-PCOS group. Furthermore, NMN inhibits endometrial cell apoptosis, improves endometrial decidualization transition, reduces IR, restores the expression of glycolysis rate-limiting enzymes, and activates the PI3K/AKT pathway in the uterus.

Conclusions

These results suggest that NMN enhances endometrial tissue homeostasis by decreasing uterine IR and regulating the glycolysis through the PI3K/AKT pathway.

Abstract Image

烟酰胺单核苷酸通过降低胰岛素抵抗和调节糖化途径改善多囊卵巢综合征大鼠模型的子宫内膜稳态
SCOPEP多囊卵巢综合征(PCOS)是一种常见的内分泌疾病,可导致胰岛素抵抗(IR)和糖代谢失调,造成子宫内膜环境失衡,不利于PCOS胚胎着床。本研究旨在探讨烟酰胺单核苷酸(NMN)是否能改善 PCOS 大鼠模型中子宫内膜的稳定性,并确定其是否与降低 IR 和提高糖酵解水平有关及其潜在的信号通路。方法和结果将雌性 Sprague-Dawley (SD) 大鼠饲喂来曲唑和高脂饮食 (HFD) 以形成 PCOS 模型,然后用或不用 NMN 处理模型大鼠。根据喂养和治疗方法随机分为对照组、PCOS 组和 PCOS-NMN 组。与多囊卵巢综合征组相比,NMN-多囊卵巢综合征组大鼠的发情周期恢复正常,血清雄激素水平(p<0.01)和空腹胰岛素水平(p<0.05)降低,子宫内膜形态改善(p<0.05)。此外,NMN 可抑制子宫内膜细胞凋亡,改善子宫内膜蜕膜化转变,降低 IR,恢复糖酵解限速酶的表达,并激活子宫内的 PI3K/AKT 通路。
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来源期刊
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research 工程技术-食品科技
CiteScore
8.70
自引率
1.90%
发文量
250
审稿时长
1.7 months
期刊介绍: Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.
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