GABA-Decorated Nanocarrier for Smart Delivery of Fludioxonil for Targeted Control of Banana Wilt Disease

IF 5.7 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2024-10-17 DOI:10.1021/acs.jafc.4c07549

Liangheng He, Chunxia Xiao, Li Zhu, Wenjie Deng, Yanheng Zhang, Yang Li, Xinzhou Wu, Hanxiang Wu, Hanhong Xu, Jinliang Jia

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Abstract

Developing a targeted nanopesticide to control the vascular disease of banana in agriculture is crucial to improve pesticide utilization. In this study, according to the degree of functionalization, three γ-aminobutyric acid (GABA)-decorated nanocarriers (PSI-GABA₈, PSI-GABA₁₈, and PSI-GABA₂₈) were constructed for smart delivery of nonsystemic fungicide in banana phloem tissues. Fludioxonil (Flu) was loaded in nanocarriers to form Flu@PSI-GABA nanoparticles with a core/shell structure for control of banana wilt disease. Results demonstrated that the delivery dosage of Flu was up to 1.6 mg/L in castor phloem sap using PSI-GABA₂₈ nanocarriers. In vitro results showed that the EC₅₀ of Flu@PSI-GABA₂₈ was 0.0116 mg/L, and the inhibitory activity was about 8.8 times higher than that of technical-grade (TC) Flu. Flu@PSI-GABA₂₈ could be transported for long distances and accumulated to the rhizome of banana by foliar application, and the control effectiveness was about 20 times that of the conventional Flu (50% WP) for the banana wilt. This study provides a distinctive guidance for effective control of vascular diseases in precision agriculture application.

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GABA 醛化纳米载体用于智能递送氟啶虫酰胺，以靶向防治香蕉枯萎病

开发一种有针对性的纳米农药来防治农业中的香蕉维管束病害对于提高农药利用率至关重要。本研究根据功能化程度，构建了三种γ-氨基丁酸（GABA）装饰的纳米载体（PSI-GABA8、PSI-GABA18 和 PSI-GABA28），用于在香蕉韧皮部组织中智能递送非系统杀菌剂。在纳米载体中加入氟啶虫腈（Flu），形成具有核/壳结构的 Flu@PSI-GABA 纳米颗粒，用于防治香蕉枯萎病。结果表明，使用 PSI-GABA28 纳米载体，Flu 在蓖麻茎液中的递送剂量可达 1.6 mg/L。体外实验结果表明，Flu@PSI-GABA28的EC50为0.0116 mg/L，抑制活性是技术级（TC）Flu的约8.8倍。通过叶面喷施，Flu@PSI-GABA28 可以长距离迁移并积累到香蕉根茎，对香蕉枯萎病的防治效果是常规 Flu（50% WP）的 20 倍左右。该研究为精准农业应用中有效防治维管束病害提供了独特的指导。

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.