Adipose tissue responds to stress-induced immunosuppression affecting immune response partially by miR-145-5p/S1PR1 pathway

IF 3.8 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Poultry Science Pub Date : 2024-10-13 DOI:10.1016/j.psj.2024.104431

Xiangnan Wang, Yi Jiang, Yuxin Zhang, Meiqi Xia, Jia Li, Chaolai Man

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引用次数: 0

Abstract

Stress-induced immunosuppression (SIIS) is one of the most common problems in intensive poultry production, which can cause immunized chickens to still develop diseases and bring huge losses to production. Recently, adipose tissue, as an immunomodulatory organ, has become a hot topic of attention. However, the function and mechanism of adipose tissue involved in SIIS and its influence on the immune response are still unclear. In this study, we dynamically analyzed the correlations between the T cells migration and change of sphingosine-1-phosphate receptor 1 (S1PR1) gene in adipose tissue using chicken models with different immune states, and further explored the regulatory mechanisms and application. The results showed that SIIS could significantly change the expressions of lymphocytes migration related S1PR1 gene, and SIIS could inhibit the Newcastle disease virus (NDV) immune response partially by affecting the migration and proliferation of TCRα⁺ T cells in adipose tissue. Moreover, the miR-145-5p/S1PR1 pathway was a potential key mechanism to regulate T cells migration in adipose tissue, and circulating miR-145-5p had potential value as a molecular marker. This research can provide innovative reference for in-depth studying the immunoregulatory function and mechanism of adipose tissue.

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脂肪组织通过 miR-145-5p/S1PR1 通路对压力诱导的免疫抑制做出反应，并部分影响免疫反应

应激诱导免疫抑制（SIIS）是集约化家禽生产中最常见的问题之一，可导致免疫鸡仍然发病，给生产带来巨大损失。近来，作为免疫调节器官的脂肪组织成为人们关注的热点。然而，脂肪组织参与 SIIS 的功能和机制及其对免疫应答的影响仍不清楚。本研究利用不同免疫状态的鸡模型，动态分析了T细胞迁移与脂肪组织中鞘磷脂-1-磷酸受体1（S1PR1）基因变化的相关性，并进一步探讨了其调控机制和应用。结果表明，SIIS能显著改变淋巴细胞迁移相关的S1PR1基因的表达，并通过影响脂肪组织中TCRα+ T细胞的迁移和增殖，部分抑制新城疫病毒（NDV）的免疫应答。此外，miR-145-5p/S1PR1通路是调控脂肪组织中T细胞迁移的潜在关键机制，循环中的miR-145-5p具有潜在的分子标记物价值。这项研究可为深入研究脂肪组织的免疫调节功能和机制提供创新性参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Poultry Science 农林科学-奶制品与动物科学

CiteScore

7.60

自引率

15.90%

发文量

审稿时长

94 days

期刊介绍： First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across all disciplines. As of January 2020, Poultry Science will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers. An international journal, Poultry Science publishes original papers, research notes, symposium papers, and reviews of basic science as applied to poultry. This authoritative source of poultry information is consistently ranked by ISI Impact Factor as one of the top 10 agriculture, dairy and animal science journals to deliver high-caliber research. Currently it is the highest-ranked (by Impact Factor and Eigenfactor) journal dedicated to publishing poultry research. Subject areas include breeding, genetics, education, production, management, environment, health, behavior, welfare, immunology, molecular biology, metabolism, nutrition, physiology, reproduction, processing, and products.