Senescent stromal fibroblasts in bladder tumors support cancer progression

IF 17 Q1 CELL BIOLOGY
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Abstract

Aging is associated with biological processes (such as the accumulation of senescent cells) that are relevant to the development of cancer. Using genetically modified mouse models, we discovered that p16high senescent cells with a secretory phenotype accumulate in the bladder during aging, which leads to cancer progression.

Abstract Image

膀胱肿瘤中的衰老基质成纤维细胞支持癌症进展。
衰老与与癌症发展相关的生物过程(如衰老细胞的积累)有关。我们利用转基因小鼠模型发现,在衰老过程中,具有分泌表型的 p16 高衰老细胞会在膀胱中积累,从而导致癌症进展。
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来源期刊
CiteScore
14.70
自引率
0.00%
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