Neuromodulation effect of temporal interference stimulation based on network computational model.

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Frontiers in Human Neuroscience Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.3389/fnhum.2024.1436205
Nafiseh Karimi, Rassoul Amirfattahi, Abolghasem Zeidaabadi Nezhad
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引用次数: 0

Abstract

Deep brain stimulation (DBS) has long been the conventional method for targeting deep brain structures, but noninvasive alternatives like transcranial Temporal Interference Stimulation (tTIS) are gaining traction. Research has shown that alternating current influences brain oscillations through neural modulation. Understanding how neurons respond to the stimulus envelope, particularly considering tTIS's high-frequency carrier, is vital for elucidating its mechanism of neuronal engagement. This study aims to explore the focal effects of tTIS across varying amplitudes and modulation depths in different brain regions. An excitatory-inhibitory network using the Izhikevich neuron model was employed to investigate responses to tTIS and compare them with transcranial Alternating Current Stimulation (tACS). We utilized a multi-scale model that integrates brain tissue modeling and network computational modeling to gain insights into the neuromodulatory effects of tTIS on the human brain. By analyzing the parametric space, we delved into phase, amplitude, and frequency entrainment to elucidate how tTIS modulates endogenous alpha oscillations. Our findings highlight a significant difference in current intensity requirements between tTIS and tACS, with tTIS requiring notably higher intensity. We observed distinct network entrainment patterns, primarily due to tTIS's high-frequency component, whereas tACS exhibited harmonic entrainment that tTIS lacked. Spatial resolution analysis of tTIS, conducted via computational modeling and brain field distribution at a 13 Hz stimulation frequency, revealed modulation in deep brain areas, with minimal effects on the surface. Notably, we observed increased power within intrinsic and stimulation bands beneath the electrodes, attributed to the high stimulus signal amplitude. Additionally, Phase Locking Value (PLV) showed slight increments in non-deep areas. Our analysis indicates focal stimulation using tTIS, prompting further investigation into the necessity of high amplitudes to significantly affect deep brain regions, which warrants validation through clinical experiments.

基于网络计算模型的时间干扰刺激神经调节效应
长期以来,脑深部刺激(DBS)一直是针对脑深部结构的传统方法,但经颅颞叶干扰刺激(tTIS)等非侵入性替代方法正日益受到重视。研究表明,交流电通过神经调制影响大脑振荡。了解神经元如何对刺激包络做出反应,尤其是考虑到 tTIS 的高频载波,对于阐明其神经元参与机制至关重要。本研究旨在探索 tTIS 在不同脑区的不同振幅和调制深度下的焦点效应。我们采用了伊日科维奇神经元模型的兴奋抑制网络来研究对 tTIS 的反应,并将其与经颅交变电流刺激(tACS)进行比较。我们利用一个多尺度模型,将脑组织建模和网络计算建模整合在一起,以深入了解 tTIS 对人脑的神经调节作用。通过分析参数空间,我们深入研究了相位、振幅和频率夹带,以阐明 tTIS 如何调节内源性阿尔法振荡。我们的研究结果表明,tTIS 和 tACS 对电流强度的要求存在显著差异,tTIS 要求的电流强度明显更高。我们观察到不同的网络夹带模式,这主要是由于 tTIS 的高频成分,而 tACS 则表现出 tTIS 所缺乏的谐波夹带。通过计算建模和 13 赫兹刺激频率下的脑场分布,对 tTIS 进行了空间分辨率分析,结果显示对大脑深部区域进行了调节,而对表层的影响微乎其微。值得注意的是,我们观察到电极下方固有波段和刺激波段内的功率增加,这归因于高刺激信号幅度。此外,锁相值(PLV)在非深部区域也有轻微增加。我们的分析表明,使用 tTIS 可以对病灶进行刺激,这促使我们进一步研究高振幅对大脑深部区域产生显著影响的必要性,这需要通过临床实验来验证。
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来源期刊
Frontiers in Human Neuroscience
Frontiers in Human Neuroscience 医学-神经科学
CiteScore
4.70
自引率
6.90%
发文量
830
审稿时长
2-4 weeks
期刊介绍: Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
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