Critical Impact of Working Distance on OCT Imaging: Correction of Optical Distortion and Its Effects on Measuring Retinal Curvature.

IF 5 2区 医学 Q1 OPHTHALMOLOGY
Yong Woo Kim, Glen P Sharpe, Julia Siber, Ralf Keßler, Jörg Fischer, Tilman Otto, Balwantray C Chauhan
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Abstract

Purpose: To assess the impact of working distance (WD) on optical distortion in optical coherence tomography (OCT) imaging and to evaluate the effectiveness of optical distortion correction in achieving consistent retinal Bruch's membrane (BM) layer curvature, regardless of variations in WD.

Methods: Ten subjects underwent OCT imaging with four serial macular volume scans, each employing distinct WD settings adjusted by balancing the sample and reference arm of the OCT interferometer (eye length settings changed). Either of two types of 30° standard objectives (SOs) was used. A ray tracing model was used to correct optical distortion, and BM layer curvature (represented as the second derivative of the curve) was measured. Linear mixed effects (LME) modeling was used to analyze factors associated with BM layer curvature, both before and after distortion correction.

Results: WD exhibited significant associations with axial length (β = -1.35, P < 0.001), SO type (P < 0.001), and eye length settings (P < 0.001). After optical distortion correction, the mean ± SD BM layer curvature significantly increased from 16.80 ± 10.08 µm-1 to 49.31 ± 7.50 µm-1 (P < 0.001). The LME model showed a significant positive association between BM layer curvature and WD (β = 1.94, P < 0.001). After distortion correction, the percentage change in BM layer curvature due to a 1-mm WD alteration decreased from 9.75% to 0.25%.

Conclusions: Correcting optical distortion in OCT imaging significantly mitigates the influence of WD on BM layer curvature, enabling a more accurate analysis of posterior eye morphology, especially when variations in WD are unavoidable.

工作距离对 OCT 成像的关键影响:光学失真校正及其对视网膜曲率测量的影响。
目的:评估工作距离(WD)对光学相干断层扫描(OCT)成像中光学畸变的影响,并评估光学畸变校正在实现一致的视网膜布鲁氏膜(BM)层曲率方面的有效性,而与 WD 的变化无关:十名受试者接受了四次连续黄斑体积扫描的 OCT 成像,每次扫描都采用了不同的 WD 设置,通过平衡 OCT 干涉仪的样本臂和参考臂进行调整(改变眼长设置)。两种 30° 标准物镜(SO)任选其一。使用光线追踪模型校正光学畸变,并测量 BM 层曲率(用曲线的二次导数表示)。使用线性混合效应(LME)模型分析了畸变校正前后与基质层曲率相关的因素:WD与轴长(β = -1.35, P < 0.001)、SO类型(P < 0.001)和眼长设置(P < 0.001)有明显的相关性。光学畸变校正后,平均 ± SD BM 层曲率从 16.80 ± 10.08 µm-1 显著增加到 49.31 ± 7.50 µm-1 (P < 0.001)。LME 模型显示,基底膜层曲率与 WD 呈显著正相关(β = 1.94,P < 0.001)。畸变校正后,因1毫米WD改变而导致的BM层曲率变化百分比从9.75%降至0.25%:结论:在 OCT 成像中纠正光学畸变可显著减轻 WD 对 BM 层曲率的影响,从而更准确地分析眼球后部形态,尤其是在 WD 变化不可避免的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
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